Document Detail

Clinical significance of first trimester crown-rump length disparity in dichorionic twin gestations.
MedLine Citation:
PMID:  15507979     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the clinical significance of first trimester crown-rump disparity in dichorionic twin gestations. STUDY DESIGN: Ultrasound examinations of dichorionic twin pregnancies between 11 and 14 weeks of gestation were evaluated for growth discordance using crown-rump length. Medical records were reviewed for antenatal complications that included spontaneous abortion, fetal death, fetal structural or chromosomal anomalies, and preterm delivery. Fisher's exact test was used for statistical analysis; a probability value of <.05 was considered significant. RESULTS: Of 159 twin pregnancies, there were 7 fetal structural anomalies, 2 fetal chromosomal anomalies, 5 second-trimester spontaneous abortions, 3 second-trimester fetal deaths, and 1 third-trimester fetal death. Pregnancies that were complicated by fetal structural or chromosomal anomalies had significantly greater median crown-rump length discordance than pregnancies without fetal anomalies (4.0 mm vs 2.0 mm; P = .02). Crown-rump length discordance >10%, which is the 90th percentile for intertwin crown-rump length disparity in our population, was associated with a significantly higher incidence of fetal anomalies (22.2% vs 2.8%; P = .01). CONCLUSION: First trimester crown-rump length disparity in dichorionic twin gestations is associated with an increased risk of fetal structural and chromosomal anomalies.
Robin B Kalish; Meruka Gupta; Sriram C Perni; Seth Berman; Stephen T Chasen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-27     Completed Date:  2004-12-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1437-40     Citation Subset:  AIM; IM    
Department of Gynecology and Obstetrics, Division of Maternal-Fetal Medicine, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA.
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MeSH Terms
Abortion, Spontaneous / epidemiology
Congenital Abnormalities / epidemiology
Crown-Rump Length*
Fetal Death / epidemiology
Fetal Development
Nuchal Translucency Measurement
Pregnancy Trimester, First*
Pregnancy, Multiple*
ROC Curve
Reproductive Techniques, Assisted
Ultrasonography, Prenatal
Comment In:
Am J Obstet Gynecol. 2005 Aug;193(2):592-3; author reply 593-4   [PMID:  16098909 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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