Document Detail


Clinical significance of expression of estrogen receptor alpha and beta mRNAs in ovarian cancers.
MedLine Citation:
PMID:  10838500     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Novel human estrogen receptor (ER)-beta was identified in cDNA libraries from human testis. ER-beta specifically expresses in testis, ovary, thymus, spleen, osteoblasts and fetus. ER-beta might not conserve the same physiological functions as does ER-alpha. Therefore, the clinical significance of the expression of ER-alpha and ER-beta mRNAs in ovarian cancers was investigated. The percentage of ER-beta mRNA to ER-alpha mRNA ranged from 1.5 to 10% in normal ovaries. On the other hand, the ratios of ER-beta mRNA to ER-alpha mRNA were in a wide range in ovarian cancers. There was no significant difference in the ratios among ovarian cancers classified according to histological types or clinical stages. In a 48-month survival rate, the patient prognosis in ovarian cancers with a low or high ratio of ER-beta mRNA to ER-alpha mRNA (<1.5 or >10% of ER-beta mRNA to ER-alpha mRNA) was significantly worse than that in ovarian cancers with a medium ratio (>==1.5 to <==10% of ER-beta mRNA to ER-alpha mRNA). In conclusion, the intact synchronized expression of ER-beta mRNA interacting with ER-alpha mRNA might be damaged in some ovarian cancers, which might lead to poor patient prognosis.
Authors:
J Fujimoto; R Hirose; H Sakaguchi; T Tamaya
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology     Volume:  58     ISSN:  0030-2414     ISO Abbreviation:  Oncology     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-18     Completed Date:  2000-07-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  334-41     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Affiliation:
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blotting, Southern
Female
Gene Expression Regulation, Neoplastic
Humans
Middle Aged
Ovarian Neoplasms / chemistry*,  genetics
Ovary / chemistry
Prognosis
RNA
RNA, Messenger / analysis
RNA, Neoplasm / analysis
Receptors, Estrogen / analysis*,  genetics
Reverse Transcriptase Polymerase Chain Reaction / methods
Chemical
Reg. No./Substance:
0/RNA primers; 0/RNA, Messenger; 0/RNA, Neoplasm; 0/Receptors, Estrogen; 63231-63-0/RNA

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