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Clinical significance of the double-peak sensory response in nerve conduction study of normal and diabetic patients.
MedLine Citation:
PMID:  23334614     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The aim of this study was to understand the meaning of the double-peak responses in digital nerve conduction study in normal and diabetic patients.
DESIGN: This was a cross-sectional and correlative study. Sixty healthy subjects (10 people per decade from 20 to 79 yrs of age; 26 men; mean age, 48 yrs) and 60 diabetic patients (10 people per decade from 22 to 79 yrs of age; 36 men, mean age, 53 yrs) were included. The composite score of the nerve conduction study was obtained. Orthodromic sensory nerve conduction studies were performed on the median nerves using submaximal stimulation. The latencies and amplitudes of first and second peaks were measured. The Toronto clinical scoring system for diabetic neuropathy was applied to all diabetic patients.
RESULTS: The first and second peak latencies of both 3- and 4-cm interpeak distance in diabetic patients were significantly increased compared with those of age-matched control subjects (P < 0.05). The correlation between the Toronto clinical scoring system and first and second peak latency and amplitude were significantly high, and the correlation between the composite score and first and second peak latency and amplitude was also related.
CONCLUSIONS: The double-peak response represents the far distal nerve pathophysiology. The authors suspect that they will find an increasing role in diagnosing the peripheral neuropathy, which starts at the distal nerve in centripetal pattern.
Kyung-Lim Joa; Chang- Hwan Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  92     ISSN:  1537-7385     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  AIM; IM    
From the Department of Rehabilitation Medicine, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan City, Korea (K-LJ); and Clinical Neurophysiology Section, Department of Physical & Rehabilitation Medicine, School of Medicine, InHa University, Incheon City, Korea (K-LJ, C-HK).
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