Document Detail


Clinical significance of cardiac damage and changes in function after exercise.
MedLine Citation:
PMID:  18614951     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute bouts of ultraendurance exercise may result in the appearance of biomarkers of cardiac cell damage and a transient reduction in left ventricular function. The clinical significance of these changes is not fully understood. There seems to be two competing issues to be resolved. First, could prolonged endurance exercise produce a degree of cardiac stress and/or damage that results, during the short or long term, in deleterious consequences for cardiac health. Second, there is a clear need to educate those responsible for the medical care of endurance athletes about the possibility of a transient reduction in cardiac function and the appearance of cTnT/cTnI after an exercise. Minor elevations in cardiac troponins are commonplace after an endurance exercise in elite and recreational athletes and may occur alongside exercise-associated collapse. Misdiagnosis of myocardial injury and subsequent mismanagement can be unnecessarily expensive and psychologically damaging to the athlete. Diagnosis of myocardial injury after prolonged exercise should be made on the basis of all available information and not blood tests alone. The clinical significance of chronic exposure to endurance exercise is unknown. The development of myocardial fibrosis has been suggested as a long-term outcome to chronic exposure to repetitive bouts of endurance exercise and has been linked to an exercise-induced inflammatory process observed in an animal model. This hypothesis is supported by a limited number of studies reporting postmortem studies in athletes and an increased prevalence of complex arrhythmia in veteran athletes. Care is warranted in promoting this hypothesis without further detailed work, given the unequivocal link between exercise and mortality and morbidity. It would seem erroneous, however, to assume that a linear relationship exists between exercise volume and cardiac health.
Authors:
Gregory P Whyte
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  40     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-18     Completed Date:  2008-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1416-23     Citation Subset:  IM; S    
Affiliation:
Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom. gregwhyte27@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac
Exercise / physiology*
Fibrosis
Heart Injuries / diagnosis,  pathology*
Humans
Physical Exertion / physiology*
Sports
Troponin / biosynthesis
Ventricular Dysfunction, Left
Chemical
Reg. No./Substance:
0/Troponin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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