Document Detail

Clinical significance of azathioprine metabolites for the maintenance of remission in autoimmune hepatitis.
MedLine Citation:
PMID:  22488741     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: TGN concentrations of >220 pmol/8 × 10(8) RBCs are associated with remission. TGN measurement may help identify inadequate immunosupression. AZA-induced cholestasis was associated with increased MeMPN concentrations.
Harpreet K Dhaliwal; Rory Anderson; Elizabeth L Thornhill; Sarah Schneider; Elaine McFarlane; Dermot Gleeson; Lynne Lennard
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-07
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  56     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-05     Completed Date:  2013-01-17     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1401-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
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MeSH Terms
Administration, Oral
Alanine Transaminase / drug effects,  metabolism
Azathioprine / adverse effects,  pharmacokinetics*,  therapeutic use*
Cohort Studies
Confidence Intervals
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Monitoring
Follow-Up Studies
Great Britain
Hepatitis, Autoimmune / blood*,  diagnosis,  drug therapy*
Immunosuppressive Agents / adverse effects,  pharmacokinetics*,  therapeutic use*
Liver Function Tests
Maximum Tolerated Dose
Methyltransferases / drug effects,  metabolism
Middle Aged
Remission Induction
Retrospective Studies
Risk Assessment
Severity of Illness Index
Statistics, Nonparametric
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Immunosuppressive Agents; EC 2.1.1.-/Methyltransferases; EC Transaminase; MRK240IY2L/Azathioprine

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