Document Detail

Clinical significance of associated nodular lesions of the adrenal in patients with aldosteronoma.
MedLine Citation:
PMID:  2368435     Owner:  NLM     Status:  MEDLINE    
Thirty-seven patients with primary aldosteronism were treated by unilateral total adrenalectomy during a 7-year period (1981-1987). The 37 patients were classified into 3 groups on the basis of adrenal pathology: unilateral solitary adenoma, 23 cases (group 1); unilateral adenomas, 3 cases (group 2); and adenoma with multiple macro- or microscopic nodules, 11 cases (group 3). The preoperative conditions of the patients (age, duration of hypertension, plasma renin activity, plasma aldosterone concentration, and serum potassium concentration), postoperative sequential changes of hormone levels, and outcome of hypertension were compared among the groups in order to determine whether the differences of adrenal pathology would affect the postoperative course. The preoperative parameters excluding age at surgery did not differ significantly among the 3 groups. The mean age in group 3, however, was slightly higher than in groups 1 and 2 (47.8 versus 42.8 versus 42.7 years). Postoperative hormonal changes were also similar, particularly in groups 1 and 3, staying within the normal range throughout the follow-up period (mean, 31 months; range, 3-86 months). However, postoperative improvement of hypertension showed marked differences, being significantly retarded in patients with multinodular lesions (group 3), about half of whom remained hypertensive even after 1 year. Nodular lesions other than adenoma(s) were, therefore, thought not to contribute to hormonal excess but to result from intractable hypertension.
Y Ito; Y Fujimoto; T Obara; T Kodama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  14     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:    1990 May-Jun
Date Detail:
Created Date:  1990-08-16     Completed Date:  1990-08-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  330-4     Citation Subset:  IM    
Department of Endocrine Surgery, Tokyo Women's Medical College, Japan.
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MeSH Terms
Adenoma / classification,  pathology*,  surgery
Hormones / physiology*
Hyperaldosteronism / classification,  complications,  pathology*,  surgery
Hypertension / etiology,  physiopathology*
Middle Aged
Reg. No./Substance:

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