| Clinical significance of antibodies to native or denatured 60-kd or 52-kd Ro/SS-A proteins in Sj?gren's syndrome. | |
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MedLine Citation:
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PMID: 8129768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the clinical significance of antibodies to native or denatured (anti-n or anti-d) 60- or 52-kd Ro/SS-A proteins (60K or 52K) in Sj?gren's syndrome (SS). METHODS: The presence of antibodies to denatured and native Ro/SS-A proteins was determined by immunoblotting and immunoprecipitation, respectively. Salivary gland dysfunction was evaluated by salivary function scintigraphy. RESULTS: The incidence of anti-d-60K without anti-d-52K was lower among patients with systemic lupus erythematosus with SS (SLE/SS) and among those with primary SS, compared with patients who had SLE without SS, whereas anti-d-52K without anti-d-60K was more common in SLE/SS patients and primary SS patients than in SLE patients without SS. All of the patients with anti-Ro/SS-A had anti-n-60K. Serologic abnormalities and salivary gland dysfunction were associated with anti-n-60K in SS, whereas Hashimoto's thyroiditis in SS was related to anti-d-60K. Anti-d-52K was not associated with any extraglandular or glandular symptoms in SS. CONCLUSION: The data indicate that anti-n-60K, which appears to recognize conformational epitopes, is associated with clinical features of SS characterized by glandular dysfunction. |
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Authors:
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K Tsuzaka; T Fujii; M Akizuki; T Mimori; T Tojo; H Fujii; Y Tsukatani; A Kubo; M Homma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 37 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-04-08 Completed Date: 1994-04-08 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 88-92 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
/
analysis,
chemistry* Autoantigens / blood, immunology* Female Humans Male Precipitin Tests Protein Denaturation RNA, Small Cytoplasmic* Ribonucleoproteins / blood, immunology* Salivary Glands / chemistry, radionuclide imaging Sjogren's Syndrome / blood, immunology* Sodium Pertechnetate Tc 99m / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Autoantigens; 0/RNA, Small Cytoplasmic; 0/Ribonucleoproteins; 0/SS-A antigen; 0/TROVE2 protein, human; 23288-60-0/Sodium Pertechnetate Tc 99m |
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