Document Detail

Clinical significance of antibodies to native or denatured 60-kd or 52-kd Ro/SS-A proteins in Sj?gren's syndrome.
MedLine Citation:
PMID:  8129768     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the clinical significance of antibodies to native or denatured (anti-n or anti-d) 60- or 52-kd Ro/SS-A proteins (60K or 52K) in Sj?gren's syndrome (SS). METHODS: The presence of antibodies to denatured and native Ro/SS-A proteins was determined by immunoblotting and immunoprecipitation, respectively. Salivary gland dysfunction was evaluated by salivary function scintigraphy. RESULTS: The incidence of anti-d-60K without anti-d-52K was lower among patients with systemic lupus erythematosus with SS (SLE/SS) and among those with primary SS, compared with patients who had SLE without SS, whereas anti-d-52K without anti-d-60K was more common in SLE/SS patients and primary SS patients than in SLE patients without SS. All of the patients with anti-Ro/SS-A had anti-n-60K. Serologic abnormalities and salivary gland dysfunction were associated with anti-n-60K in SS, whereas Hashimoto's thyroiditis in SS was related to anti-d-60K. Anti-d-52K was not associated with any extraglandular or glandular symptoms in SS. CONCLUSION: The data indicate that anti-n-60K, which appears to recognize conformational epitopes, is associated with clinical features of SS characterized by glandular dysfunction.
K Tsuzaka; T Fujii; M Akizuki; T Mimori; T Tojo; H Fujii; Y Tsukatani; A Kubo; M Homma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  37     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-08     Completed Date:  1994-04-08     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  88-92     Citation Subset:  AIM; IM    
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MeSH Terms
Autoantibodies / analysis,  chemistry*
Autoantigens / blood,  immunology*
Precipitin Tests
Protein Denaturation
RNA, Small Cytoplasmic*
Ribonucleoproteins / blood,  immunology*
Salivary Glands / chemistry,  radionuclide imaging
Sjogren's Syndrome / blood,  immunology*
Sodium Pertechnetate Tc 99m / diagnostic use
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens; 0/RNA, Small Cytoplasmic; 0/Ribonucleoproteins; 0/SS-A antigen; 0/TROVE2 protein, human; 23288-60-0/Sodium Pertechnetate Tc 99m

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