Document Detail


Clinical significance of antibodies against tropomyosin, actin and myosin in patients with dilated cardiomyopathy.
MedLine Citation:
PMID:  7932629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study we evaluated the importance of autoimmune mechanisms in dilated cardiomyopathies. Sera from 81 patients with dilated cardiomyopathy, 17 patients with various other cardiologic diseases and 40 apparently healthy blood donors were tested with an immunoassay method for the presence of autoantibodies against tropomyosin, myosin and actin, three antigens which are components of the cardiac tissue. Elevated values of autoantibodies were obtained in a high percentage of patients with dilated cardiomyopathy as compared to the control group (66% antitropomyosin IgG, 66% antimyosin IgG, 28.3% antitropomyosin IgM). It has also been shown, for the first time, that patients with dilated cardiomyopathy and positive for at least one of the screened autoantibodies had a thicker interventricular septum thickness, systolic and diastolic than patients negative for the presence of autoantibodies (1.18 +/- 0.3, 1.2 +/- 0.3 vs 0.88 +/- 0.1, 0.9 +/- 0.2 respectively), a finding that indicates the importance of these autoantibodies. Although further investigation is needed, it is concluded that the detection of these autoantibodies can be a useful tool for the diagnosis, follow-up and prognosis of the patients with dilated cardiomyopathy.
Authors:
M M Konstadoulakis; H Kroumbouzou; E Tsiamis; A Trikas; P Toutouzas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical & laboratory immunology     Volume:  40     ISSN:  0141-2760     ISO Abbreviation:  J Clin Lab Immunol     Publication Date:  1993  
Date Detail:
Created Date:  1994-10-28     Completed Date:  1994-10-28     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7808987     Medline TA:  J Clin Lab Immunol     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  61-7     Citation Subset:  IM    
Affiliation:
Dept. of Cardiology, University of Athens, School of Medicine, Greece.
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MeSH Terms
Descriptor/Qualifier:
Actins / immunology*
Adult
Aged
Autoantibodies / blood*
Autoimmunity
Cardiomyopathy, Dilated / complications,  immunology*,  pathology
Enzyme-Linked Immunosorbent Assay
Female
Heart Septum / pathology,  ultrasonography
Heart Ventricles / pathology,  ultrasonography
Humans
Immunoglobulin G / blood
Immunoglobulin M / blood
Male
Middle Aged
Myosins / immunology*
Tropomyosin / immunology*
Chemical
Reg. No./Substance:
0/Actins; 0/Autoantibodies; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Tropomyosin; EC 3.6.4.1/Myosins

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