Document Detail

Clinical significance of Koebner's phenomenon in vitiligo.
MedLine Citation:
PMID:  22709360     Owner:  NLM     Status:  Publisher    
Background:  The clinical significance of Koebner's phenomenon (KP) in vitiligo with respect to disease activity and course is still debatable. Recently, a new classification is introduced for the assessment of KP. Objectives:  To evaluate the new assessment method for KP in clinical practice and to determine its clinical significance, both with respect to the clinical profile, course of vitiligo and treatment response. Methods:  Seven hundred generalized vitiligo patients were included in this observational cohort study. KP was classified according to the new classification system in different subtypes [KP1: by history, KP2A and KP2B: by clinical examination (A: lesions on friction areas, B: linear, artefactual lesions)]. Results:  KP1 was positive in 34.1% of the patients, 66.3% were KP2A positive and 15.1% had KP2B. The BSA was significantly (P<0.001) higher in presence of any KP subtype and more disease activity was found in KP1+ and KP2B+ patients. An earlier age of onset and elevated risk of further depigmentation despite treatment was observed in all KP positive groups. In KP2A+ and KP2B+ patients, depigmentation of wrists/ankles was more common. In the KP2A+ group, a significant higher prevalence of thyroid disease was found while autoimmune diseases were less prevalent in KP2B+ patients. Conclusion:  The new assessment method for KP, taking into account both history and clinical examination, seems to be a useful and valuable tool to asses KP in daily practice. Our results support the hypothesis that KP may function as a clinical parameter to assess and predict the clinical profile and course of vitiligo.
N van Geel; R Speeckaert; J De Wolf; S Bracke; I Chevolet; L Brochez; J Lambert
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-18
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 British Association of Dermatologists.
Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
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