| Clinical significance of EphA2 expression in squamous-cell carcinoma of the head and neck. | |
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MedLine Citation:
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PMID: 20614133 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: EphA2 receptor tyrosine kinase is frequently overexpressed and functionally altered in a variety of human cancers. The study aimed to assess EphA2 expression and to explore its roles in squamous-cell carcinoma of the head and neck (SCCHN). METHODS: EphA2 expression in 98 primary SCCHN tissue specimens was analyzed by immunohistochemistry and correlated with clinicopathological parameters. Additionally, 13 paired SCCHN tissues and 6 SCCHN cell lines were evaluated for EphA2 expression by RT-PCR and immunoblotting. RESULTS: EphA2 overexpressed in SCCHN tissues and SCCHN cell lines. More importantly, high EphA2 expression was significantly associated with tumor site, T classification, clinical stage, recurrence, and lymph node metastasis, respectively. Patients with high EphA2 expression had both poorer disease-free survival and overall survival than patients with low EphA2 expression. Multivariate Cox regression analysis revealed that EphA2 overexpression was an independent prognostic factor for patients with SCCHN. CONCLUSIONS: These findings suggested that EphA2 may contribute to SCCHN progression and represent a novel prognostic indicator for patients with SCCHN. |
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Authors:
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Yong Liu; Xin Zhang; Yuanzheng Qiu; Donghai Huang; Shuai Zhang; Li Xie; Lin Qi; Changyun Yu; Xiaojuan Zhou; Guoqing Hu; Yongquan Tian |
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Publication Detail:
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Type: Journal Article Date: 2010-07-08 |
Journal Detail:
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Title: Journal of cancer research and clinical oncology Volume: 137 ISSN: 1432-1335 ISO Abbreviation: J. Cancer Res. Clin. Oncol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902060 Medline TA: J Cancer Res Clin Oncol Country: Germany |
Other Details:
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Languages: eng Pagination: 761-9 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, Hunan, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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