Document Detail


Clinical significance of B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
MedLine Citation:
PMID:  22065972     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: BAFF (B cell-activating factor) and APRIL (a proliferation-inducing ligand) are members of the tumor necrosis factor family and promote B cell survival and proliferation. We evaluated the correlation between serum concentration of BAFF or APRIL and severity of acute graft-versus-host disease (GVHD).
METHODS: Fifteen patients who received allogeneic hematopoietic stem transplantation for leukemia and developed acute GVHD were enrolled. We determined serum concentrations of BAFF and APRIL at the onset of the first clinical manifestation of GVHD by enzyme-linked immunosorbent assay.
RESULTS: Nine patients had grade 2 acute GVHD, and 6 had grade 3-4 acute GVHD. The BAFF serum concentration was higher in patients with grade 3-4 acute GVHD (1,093.42 in grade 2 vs. 2,171.99 pg/mL in grade 3-4), although the difference was not significant (P=0.077). However, the ratio of BAFF serum concentration to absolute lymphocyte count (ALC) (BAFF/ALC) was significantly higher in patients with grade 3-4 acute GVHD (P=0.045). The APRIL serum concentration and APRIL/ALC ratio showed similar results (P=0.077 and P=0.013, respectively).
CONCLUSION: Patients with grade 3-4 acute GVHD had higher BAFF/ALC and APRIL/ALC ratios than patients with grade 2 acute GVHD. These findings suggest that B cells might play an important role in the development of acute GVHD, and that the BAFF and APRIL concentrations in serum might be significant predictive factors for estimating the severity of acute GVHD. Their clinical significance should be further evaluated in a larger patient population.
Authors:
Jin Seok Kim; Soo-Jeong Kim; June-Won Cheong; Yundeok Kim; Doh Yu Hwang; Sulhee Yoon; Jieun Jang; Shin Young Hyun; Yoo Hong Min
Publication Detail:
Type:  Journal Article     Date:  2011-09-30
Journal Detail:
Title:  The Korean journal of hematology     Volume:  46     ISSN:  2092-9129     ISO Abbreviation:  Korean J Hematol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-11-08     Completed Date:  2011-11-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101486388     Medline TA:  Korean J Hematol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  -    
Affiliation:
Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
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