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Clinical and serological features of acute sensory ataxic neuropathy with antiganglioside antibodies.
MedLine Citation:
PMID:  22734901     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
There is as yet no consensus for considering pure acute sensory ataxic neuropathy (ASAN) as a variant of Guillain-Barré syndrome (GBS). Reactivity against gangliosides sharing disialosyl epitopes has been reported in these patients. The aim of this study was to determine the spectrum of reactivity against gangliosides in ASAN and to define the clinical pattern. From our database we identified patients with suspicion of ASAN. We defined ASAN as the presence of ataxia of peripheral origin with loss of proprioception, and areflexia, absence of ophthalmoplegia and no or minimal muscle weakness. Patients who met these criteria were retrospectively reviewed for their spectrum of reactivity against gangliosides and clinical features. We identified 12 patients fulfilling pre-defined criteria for ASAN. Reactivity against gangliosides containing disialosyl epitopes was present in seven patients. Concomitant reactivity against other gangliosides was present in 6/7 patients. All patients presented good prognosis and an antecedent illness was present in nine. Our results support the previously described clinico-immunological association between ASAN and disialosyl specificity, and widen the spectrum of reactivity against gangliosides. The acute presentation with a monophasic course, and good prognosis in all cases, together with transient immunoglobulin G antiganglioside antibodies and infectious antecedent in 7/12 patients support the inclusion of ASAN as a GBS variant.
Authors:
Ricard Rojas-García; Luis Querol; Eduard Gallardo; Noemi De Luna Salva; Cándido Juarez; Mercedes Garces; Eva Fages; Carlos Casasnovas; Isabel Illa
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of the peripheral nervous system : JPNS     Volume:  17     ISSN:  1529-8027     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9704532     Medline TA:  J Peripher Nerv Syst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  158-168     Citation Subset:  -    
Copyright Information:
© 2012 Peripheral Nerve Society.
Affiliation:
Neuromuscular Diseases Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, and Laboratory of Experimental Neurology, Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona Centro de Investigación Biomédica en Red de Neurodegeneración (CIBERNED), Barcelona Department of Immunology Hospital de la Santa Creu i Sant Pau, Barcelona Department of Neurology, Hospital de Manises, Valencia Department of Neurology, Hospital Santa Maria del Rosell, Cartagena Department of Neurology, Hospital Universitari de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.
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