Document Detail

Clinical role for a superantigen in Yersinia pseudotuberculosis infection.
MedLine Citation:
PMID:  9109426     Owner:  NLM     Status:  MEDLINE    
Yersinia pseudotuberculosis is an enteric pathogen that causes a variety of clinical symptoms in the human. Recently, we reported the production of a superantigen (Y. pseudotuberculosis-derived mitogen, YPM) by this organism and characterized the gene structure of ypm. To further study the potential pathogenic role of YPM in Y. pseudotuberculosis infection, we assayed IgG anti-YPM antibodies and T cell antigen receptor-Vbeta expression of the T cells in peripheral blood and in mesenteric lymph node in patients acutely infected with Y. pseudotuberculosis. 20 out of 33 patients (61%) had an elevated antibody titer compared with healthy controls (P = 0.0001). Patients with systemic symptoms such as lymphadenopathy, transient renal dysfunction, and arthritis had significantly higher titers of anti-YPM than patients with gastrointestinal tract symptoms alone. T cells bearing the Vbeta3 gene segment were significantly increased (P = 0.009) among acute phase patients compared with healthy children. During the convalescence phase of the illness, there was a reduction in the abnormal level of Vbeta3 T cells. Moreover, in the mesenteric lymph node, an elevated level of Vbeta3 T cells compared with peripheral blood and a sequence diversity in the junctional region of the T cell antigen receptor beta-chain containing Vbeta3 element was observed in one patient. Together, these findings suggest that YPM was produced in vivo and played an important role in the pathogenesis of Y. pseudotuberculosis infection.
J Abe; M Onimaru; S Matsumoto; S Noma; K Baba; Y Ito; T Kohsaka; T Takeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  99     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-05-09     Completed Date:  1997-05-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1823-30     Citation Subset:  AIM; IM    
Department of Child Ecology, The National Children's Hospital Medical Research Center, Setagaya-ku, Tokyo, Japan.
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MeSH Terms
Amino Acid Sequence
Antibodies, Bacterial / blood
Bacterial Proteins / biosynthesis
Child, Preschool
Immunoglobulin G / blood
Lymph Nodes / immunology
Mitogens / biosynthesis
Receptors, Antigen, T-Cell, alpha-beta / genetics,  metabolism
Superantigens* / biosynthesis
T-Lymphocytes / immunology
Virulence / immunology
Yersinia pseudotuberculosis / immunology*,  pathogenicity
Yersinia pseudotuberculosis Infections / etiology*,  microbiology
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Immunoglobulin G; 0/Mitogens; 0/Receptors, Antigen, T-Cell, alpha-beta; 0/Superantigens; 0/Yersinia pseudotuberculosis-derived mitogen

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