Document Detail

Clinical role of estimation metabolic syndrome's components in type 2 diabetic population with symptomatic coronary artery disease--a comparison of two criteria.
MedLine Citation:
PMID:  20645505     Owner:  NLM     Status:  MEDLINE    
Objective of our study was to estimate the metabolic syndrome (MSy)' components in type 2 diabetic subjects (T2D) with symptomatic coronary artery disease (CAD): arterial hypertension, waist circumference, triglyceridemia and plasma level of HDL, in order to define their clinical role in angina severity status. Second objective was to compare Adult Treatment Panel (ATP III) and International Diabetes Federation (IDF) criteria in testing of association MSy with current coronary status of population. Three hundred and twenty seven pts with T2D and manifested CAD were randomly included in a survey. Angina severity was assessed with the Canadian Cardiovascular Society (CCS). Data relieved MSyand its components, defined by ATP III, with predictive role for advanced angina stages. Presence of MSy is predictive for CCS3 angina severity (OR 9,93, 95% CI 0,78-126,28). Increased waist is a predictor for CCS3 (OR 1,22, 95% CI 0,27-5,46) and CCS4 symptoms onset (OR 1,55, 95% CI 0,36-6,73). CCS4 severity symptom is independently associated with arterial hypertension (OR 3,72, 95% CI 1,03-13,40) and hypertriglyceridemia (OR 1,72, 95% CI 0,42- 7,00). MSy components: increased waist, arterial hypertension and hypertriglyceridemia have been found predictive for angina CCS4 stage in T2D subjects, when IDF criteria were used. These findings raise the question of importance of metabolic syndrome and its individual constellations in T2D subjects with CAD. Results indicate that both criteria ATP III and IDF are reliable to define MSy in predictive model for coronary clinical status in T2D population.
Marijan Bosevski; Gordana Pemovska; Golubinka Bosevska; Ljubica Georgievska-Ismail
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Medicinski arhiv     Volume:  64     ISSN:  0350-199X     ISO Abbreviation:  Med Arh     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400722     Medline TA:  Med Arh     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  144-6     Citation Subset:  IM    
Faculty of Medicine Skopje, University Cardiology Clinic, Skopje, Macedonia.
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MeSH Terms
Angina Pectoris / classification,  complications
Coronary Artery Disease / complications*
Diabetes Mellitus, Type 2 / complications*
Hypertension / complications,  diagnosis
Lipids / blood
Metabolic Syndrome X / complications,  diagnosis*
Middle Aged
Reg. No./Substance:

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