| Clinical role of 18F-FDG PET-CT in suspected and potentially operable cholangiocarcinoma: a prospective study compared with conventional imaging. | |
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MedLine Citation:
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PMID: 18177454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study was conducted to evaluate the clinical role of integrated positron emission and computed tomography (PET-CT) in patients with suspected and potentially operable cholangiocarcinoma. METHODS: Between October 2005 and May 2007, 123 patients with suspected cholangiocarcinoma were enrolled in this study after diagnostic workup, including biliary dynamic computed tomography (CT) and magnetic resonance imaging/magnetic resonance cholangiopancreatography (MRI/MRCP) with magnetic resonance (MR) angiography. Patients with overt unresectable cholangiocarcinoma or gallbladder cancer diagnosed via conventional imaging were excluded. Consecutively, each enrolled patient underwent PET-CT. Data were prospectively collected and analyzed in comparison with CT and MRI/MRCP. RESULTS: The overall values for sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET-CT in primary tumor detection were 84.0%, 79.3%, 92.9%, 60.5%, and 82.9%, respectively. PET-CT demonstrated no statistically significant advantage over CT and MRI/MRCP in the diagnosis of primary tumor. According to different morphologic characteristics of cholangiocarcinoma, PET-CT showed no significant difference in detecting those of mass-forming, periductal-infiltrating, and intraductal-growing types. PET-CT revealed significantly higher accuracy over CT in the diagnosis of regional lymph nodes metastases (75.9%vs 60.9%, P= 0.004) and distant metastases (88.3%vs 78.7%, P= 0.004). Additional use of PET-CT for assessing resectability correctly showed different results from those determined by conventional imaging in 15 (15.9%) of 94 patients with cholangiocarcinoma. CONCLUSIONS: PET-CT improved the accuracy of preoperative staging in patients with cholangiocarcinoma planning to undergo curative resection. Thus, PET-CT had an important clinical impact on the selection of proper treatment. |
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Authors:
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Ji Y Kim; Myung-Hwan Kim; Tae Y Lee; Chang Y Hwang; Jae S Kim; Sung-Cheol Yun; Sang S Lee; Dong W Seo; Sung K Lee |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-01-02 |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 103 ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-14 Completed Date: 2008-05-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 1145-51 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bile Duct Neoplasms / pathology, radionuclide imaging*, surgery Bile Ducts, Extrahepatic / pathology, radionuclide imaging*, surgery Bile Ducts, Intrahepatic / pathology, radionuclide imaging*, surgery Biopsy Cholangiocarcinoma / pathology, radionuclide imaging*, surgery Cholangiopancreatography, Magnetic Resonance Female Fluorodeoxyglucose F18 / diagnostic use* Humans Image Processing, Computer-Assisted* Lymphatic Metastasis / pathology, radionuclide imaging Magnetic Resonance Angiography Male Middle Aged Neoplasm Staging Positron-Emission Tomography* Prospective Studies Sensitivity and Specificity Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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