| Clinical responses of patients with Kawasaki disease to different brands of intravenous immunoglobulin. | |
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MedLine Citation:
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PMID: 16423595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether different brands of intravenous immunoglobulin (IVIG) administered to children with Kawasaki disease (KD) result in different outcomes. STUDY DESIGN: We analyzed children with KD and divided them into 4 groups according to the brand of IVIG. A coronary artery abnormality (CAA) was defined as having a lumen diameter (inner border to inner border) of > or =3 mm in KD cases <5 years old and > or =4 mm in cases > or =5 years old, and giant aneurysm was defined as a lumen diameter > or =8 mm. Patients were considered nonresponsive to IVIG therapy if fever persisted longer than 2 days after completion of treatment and needed retreatment with IVIG. RESULTS: We collected 437 cases, 29 (6.6%) were nonresponsive, 17 (3.9%) had CAA at convalescence, and 3 (0.7%) had giant aneurysm, 2 of whom had development of myocardial infarcts. Patients receiving Brand C IVIG, prepared with beta-propiolactone, had higher rates (10%, 9/93, P = .01) of CAA at convalescence and nonresponsiveness (13%, 12/93, P = .001); giant aneurysm occurred in 3/93 (3%) receiving Brand C IVIG and in 0/344 who received the other 3 brands (P = .008). CONCLUSIONS: IVIG, prepared with beta-propiolactone, was most significantly associated with nonresponsiveness, CAA at convalescence, and giant aneurysm. Physicians should be cautious when using IVIG prepared with beta-propiolactone or enzyme digestion to treat KD. |
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Authors:
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Ming-Han Tsai; Yhu-Chering Huang; Meng-Hsiu Yen; Chung-Chen Li; Cheng-Hsun Chiu; Pen-Yi Lin; Tzou-Yien Lin; Luan-Yin Chang |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 148 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-20 Completed Date: 2006-07-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 38-43 Citation Subset: AIM; IM |
Affiliation:
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Division of Pediatric Infectious Diseases, Division of Taipei Pediatrics, Department of Pediatrics, Chang-Gung Children's Hospital, Taoyuan, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Convalescence Coronary Aneurysm / chemically induced Female Fever / chemically induced Humans Immunoglobulins, Intravenous / adverse effects, therapeutic use* Infant Male Mucocutaneous Lymph Node Syndrome / drug therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2006 Jan;148(1):6-8
[PMID:
16423589
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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