| Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants. | |
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MedLine Citation:
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PMID: 17420209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia). |
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Authors:
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Carmen D Zorrilla; Russell Van Dyke; Arlene Bardeguez; Edward P Acosta; Betsy Smith; Michael D Hughes; Sharon Huang; D Heather Watts; Barbara Heckman; Eleanor Jiménez; George McSherry; Lynne Mofenson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-04-09 |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 51 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-22 Completed Date: 2007-08-17 Revised Date: 2013-04-26 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
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Languages: eng Pagination: 2208-10 Citation Subset: IM |
Affiliation:
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Obstetrics and Gynecology Department, UPR School of Medicine, P.O. Box 365067, San Juan, Puerto Rico. czorrilla@rcm.upr.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents*
/
administration & dosage,
adverse effects,
therapeutic use Drug Therapy, Combination Female HIV Infections / drug therapy*, virology HIV-1 / drug effects Humans Infant Infant, Newborn Infectious Disease Transmission, Vertical / prevention & control Microbial Sensitivity Tests Mothers Pregnancy Pregnancy Complications, Infectious / drug therapy*, virology RNA, Viral / blood Reverse Transcriptase Inhibitors* / administration & dosage, adverse effects, therapeutic use Ritonavir* / administration & dosage, adverse effects, therapeutic use Saquinavir* / administration & dosage, adverse effects, therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/RNA, Viral; 0/Reverse Transcriptase Inhibitors; 0/Ritonavir; 127779-20-8/Saquinavir |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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