| Clinical response to an oral prostaglandin analogue in patients with interstitial cystitis. | |
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MedLine Citation:
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PMID: 9676414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the efficacy of the oral prostaglandin analogue misoprostol in controlling the symptoms of interstitial cystitis in patients with refractory disease. METHODS: Twenty-five patients were commenced on misoprostol 600 micrograms daily for 3 months. Patients who responded to therapy were offered treatment for a further 6 months. Assessment of the response was by a voiding log and an interstitial cystitis symptom score. RESULTS: At 3 months, 14 patients (56%) had significantly improved, and after a further 6 months, 12 patients (48%) had a sustained response. The incidence of adverse drug effects was 64%. Most side effects were minimal, and the response rate in patients who were able to tolerate the drug was 87% at 3 months and 75% at 9 months. CONCLUSIONS: The oral prostaglandin analogue misoprostol is effective in treating the symptoms of interstitial cystitis. It is possible that prostaglandins have a cytoprotective action in the urinary bladder. |
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Authors:
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J D Kelly; M R Young; S R Johnston; P F Keane |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase II; Journal Article |
Journal Detail:
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Title: European urology Volume: 34 ISSN: 0302-2838 ISO Abbreviation: Eur. Urol. Publication Date: 1998 |
Date Detail:
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Created Date: 1998-09-24 Completed Date: 1998-09-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7512719 Medline TA: Eur Urol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 53-6 Citation Subset: IM |
Affiliation:
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Department of Urology, Belfast City Hospital, Northern Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Aged, 80 and over Cystitis, Interstitial / drug therapy* Female Humans Male Middle Aged Misoprostol / administration & dosage*, adverse effects |
| Chemical | |
Reg. No./Substance:
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59122-46-2/Misoprostol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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