Document Detail

Clinical relevance of postprandial lipaemia.
MedLine Citation:
PMID:  16101498     Owner:  NLM     Status:  MEDLINE    
Several studies showed that after a fatty meal, plasma triglyceride (TG) levels are higher in patients with coronary heart disease. This abnormality may explain why some individuals develop atherosclerotic disease despite normal fasting lipid values. TG-rich lipoproteins are involved in atherosclerosis and thrombosis. TG, remnant-like particle (RLP) cholesterol (RLP-C) and RLP-TG increase after fat load and could contribute to atherothrombosis. Postprandial lipaemia is not a uniform abnormality. Its pathophysiology is not yet entirely clarified; possibly, the response to dietary fat is a polygenic phenomenon. However, a link with insulin resistance is likely; this link as well as that with obesity is discussed. A substantial part of life is spent in the postprandial state. Therefore, several investigators described fat load tests. However, it is still difficult to establish normal postprandial TG ranges since only small numbers of subjects were studied and there is as yet no standardised method. A more simplified fat load test should be established for 'routine' use. In this review, we consider the metabolic features, prevalence and management of postprandial lipaemia. Treatment may involve lifestyle measures as well as the use of lipid lowering (e.g. fibrates or statins), weight reducing and hypoglycaemic drugs.
Genovefa D Kolovou; Katherine K Anagnostopoulou; Stella S Daskalopoulou; Dimitri P Mikhailidis; Dennis V Cokkinos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  12     ISSN:  0929-8673     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-16     Completed Date:  2005-09-12     Revised Date:  2007-02-12    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1931-45     Citation Subset:  IM    
Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
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MeSH Terms
Antilipemic Agents / therapeutic use
Cholesterol / physiology
Coronary Disease / drug therapy,  physiopathology
Dietary Fats
Hyperlipidemias / physiopathology*,  therapy
Lipoproteins / physiology
Postprandial Period*
Triglycerides / physiology
Reg. No./Substance:
0/Antilipemic Agents; 0/Dietary Fats; 0/Lipoproteins; 0/Triglycerides; 0/remnant-like particle cholesterol; 57-88-5/Cholesterol

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