| Clinical relevance of intrinsic sympathomimetic activity of beta blockers. | |
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MedLine Citation:
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PMID: 6119937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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beta-Blockers are effective in the symptomatic relief of angina pectoris by decreasing myocardial oxygen demand during effort and emotional stress. Agents with ISA such as pindolol produce effective beta-blockade during effort or emotional stress while conferring significant protection from myocardial depression and bradycardia at rest. In addition, agents with ISA have been shown to depress respiratory function to a lesser extent and to induce fewer peripheral vascular side effects than compounds devoid of this property. These potential effects of ISA may be counterbalanced by the consideration that ISA may be undesirable in angina occurring at rest or at low exercise levels. Additional well-controlled trials in patients with angina and resting bradycardia or impaired left ventricular function are needed to further document the clinical importance of ISA. |
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Authors:
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J B Kostis; E A DeFelice; W Frishman; M Hosler; S K Krieger; N Aglitz; P T Kuo |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Review |
Journal Detail:
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Title: Angiology Volume: 32 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 1981 Nov |
Date Detail:
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Created Date: 1982-03-22 Completed Date: 1982-03-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 780-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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therapeutic use Adrenergic beta-Antagonists / adverse effects, therapeutic use* Angina Pectoris / drug therapy*, etiology Bronchial Spasm / chemically induced Double-Blind Method Heart Rate / drug effects Humans Physical Exertion Pindolol / therapeutic use Propranolol / therapeutic use Sympathomimetics / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Sympathomimetics; 13523-86-9/Pindolol; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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