Document Detail


Clinical relevance of intrinsic sympathomimetic activity of beta blockers.
MedLine Citation:
PMID:  6119937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
beta-Blockers are effective in the symptomatic relief of angina pectoris by decreasing myocardial oxygen demand during effort and emotional stress. Agents with ISA such as pindolol produce effective beta-blockade during effort or emotional stress while conferring significant protection from myocardial depression and bradycardia at rest. In addition, agents with ISA have been shown to depress respiratory function to a lesser extent and to induce fewer peripheral vascular side effects than compounds devoid of this property. These potential effects of ISA may be counterbalanced by the consideration that ISA may be undesirable in angina occurring at rest or at low exercise levels. Additional well-controlled trials in patients with angina and resting bradycardia or impaired left ventricular function are needed to further document the clinical importance of ISA.
Authors:
J B Kostis; E A DeFelice; W Frishman; M Hosler; S K Krieger; N Aglitz; P T Kuo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Review    
Journal Detail:
Title:  Angiology     Volume:  32     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  780-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / therapeutic use
Adrenergic beta-Antagonists / adverse effects,  therapeutic use*
Angina Pectoris / drug therapy*,  etiology
Bronchial Spasm / chemically induced
Double-Blind Method
Heart Rate / drug effects
Humans
Physical Exertion
Pindolol / therapeutic use
Propranolol / therapeutic use
Sympathomimetics / therapeutic use*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Sympathomimetics; 13523-86-9/Pindolol; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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