Document Detail


Clinical relevance of hibernating myocardium in ischemic left ventricular dysfunction.
MedLine Citation:
PMID:  21035587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with chronic ischemic left ventricular dysfunction may have a substantial amount of viable, hibernating myocardium, which is a state of chronic contractile dysfunction with reduced blood flow at rest. Coronary revascularization in these patients may result in improvement of left ventricular function; in the absence of viability, left ventricular function will not improve postrevascularization. Various noninvasive imaging techniques are available for detection of viable myocardium, including magnetic resonance imaging, dobutamine stress echocardiography, and nuclear imaging with single photon emission computed tomography or positron emission tomography. Because these techniques probe different characteristics of viable myocardium, the sensitivities and specificities of the techniques are not precisely identical; in general, dobutamine stress echocardiography has the highest specificity, whereas the nuclear techniques have the highest sensitivity. The presence of myocardial viability also is related to prognosis: patients with viable myocardium who undergo revascularization have a good prognosis, whereas patients with viable myocardium who are treated medically have poor outcome. Accordingly, assessment of viability is important in the therapeutic decision-making process of patients with chronic ischemic left ventricular dysfunction.
Authors:
Arend F L Schinkel; Jeroen J Bax; Victoria Delgado; Don Poldermans; Shahbudin H Rahimtoola
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  123     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  978-86     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Cardiomyopathies / complications*,  diagnosis,  surgery
Echocardiography
Humans
Magnetic Resonance Imaging
Myocardial Ischemia / complications*,  diagnosis,  surgery
Myocardial Revascularization
Positron-Emission Tomography
Prognosis
Tomography, Emission-Computed, Single-Photon
Ventricular Dysfunction, Left / complications*,  diagnosis,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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