Document Detail

Clinical relevance of T-cell receptor delta gene rearrangements in childhood B-precursor cell acute lymphoblastic leukaemia.
MedLine Citation:
PMID:  9375746     Owner:  NLM     Status:  MEDLINE    
The large majority of childhood B-precursor cell acute lymphoblastic leukaemia cases present IgH and TCRdelta gene rearrangements. These rearrangements have been widely used as specific markers for monitoring minimal residual disease. However, their prognostic value still remains unclear. In order to determine whether IgH and TCRdelta gene rearrangements have any influence on relapse and event-free survival (EFS), we analysed the clinical impact of these genetic characteristics in 51 B-precursor acute lymphoblastic leukaemia patients. 46/51 patients (90.2%) showed IgH gene rearrangements by Southern blot and/or polymerase chain reaction (PCR) analysis. No statistically significant associations were found between IgH gene rearrangement pattern and age, sex, WBC count, immunophenotype, risk factor, relapse or EFS. 27/41 patients (66%) showed Vdelta2Ddelta3 recombination by Southern blot and/or PCR analysis. At a median follow-up of 53 months the estimated 5-year EFS probability was 78 +/- 3% for the whole group. The EFS probability among patients with a Vdelta2Ddelta3 recombination pattern in the TCRdelta locus was 90 +/- 3%, whereas for patients without Vdelta2Ddelta3 recombination was 39 +/- 13% (P < 0.005). IgH rearrangement patterns do not appear to influence relapse or EFS probability. However, TCRdelta gene rearrangement patterns have a relevant impact on the relapse rate and the EFS probability. Patients with Vdelta2Ddelta3 recombination have better clinical outcome than patients without this recombination, independent of any other prognostic factors.
M A Díaz; F Garcia-Sanchez; J L Vicario; M Ramirez; A Balas; L Madero
Related Documents :
22783896 - Importance of potent p2y(12) receptor blockade in acute myocardial infarction: focus on...
22644206 - Obsessive-compulsive aspects as predictors of poor response to treatments in patients w...
8329816 - Streptococcus mitis septicemia in leukemia patients; clinical features and outcome.
9084196 - Mucormycosis of the mandible after dental extractions in a patient with acute myelogeno...
19139696 - Peritoneal dialysis masking symptoms of an insulinoma uncovered during the perioperativ...
15319026 - No seizure exacerbation from risperidone in youth with comorbid epilepsy and psychiatri...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  99     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-23     Completed Date:  1997-12-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  308-13     Citation Subset:  IM    
Department of Paediatric Haematology and Oncology, Hospital Niño Jesús, Autonomous University of Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blotting, Southern
Child, Preschool
Disease-Free Survival
Follow-Up Studies
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
Infant, Newborn
Polymerase Chain Reaction
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Comment In:
Br J Haematol. 1998 Jul;102(2):629-30   [PMID:  9695985 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The venous thrombosis risk factor 20210 A allele of the prothrombin gene is not a major risk factor ...
Next Document:  Monitoring minimal residual disease in peripheral blood in B-lineage acute lymphoblastic leukaemia.