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Clinical recommendations of Cochrane reviews in pediatric gastroenterology: A systematic analysis.
MedLine Citation:
PMID:  24978114     Owner:  NLM     Status:  Publisher    
BACKGROUND: Systematic and up-to-date Cochrane reviews in pediatrics in general and in pediatric gastroenterology in particular are important tools in disseminating the best available evidence to the medical community, thus providing the physician at the bedside with invaluable information and recommendations with regard to specific clinical questions.
MATERIALS AND METHODS: We conducted a systematic literature review including all Cochrane reviews published by the Cochrane Review Group in the field of pediatric gastroenterology between 1993 and 2012. Main outcome variables: Percentage of reviews that concluded that a certain intervention provided a benefit, percentage of reviews that concluded that a certain intervention should not be performed and percentage of studies that concluded that the current level of evidence was inconclusive.
RESULTS: In total, 86 reviews in the field of pediatric gastroenterology were included. The majority of reviews assessed pharmacological interventions (46/86); other important fields included prevention (15/86) and nutrition (9/86). 33/86 reviews issued definite recommendations (positive: 19/86: negative: 14/86). The remaining 53/86 reviews were either inconclusive (24/86) or only of limited conclusiveness (29/86). The percentage of inconclusive reviews increased from 9% (1998-2002) to 19% (2003-2007; p<0.05) to finally 24% (2008-2012) (p< 0.05). The three most common reasons for the need for further research were heterogeneity of studies (26/86), small numbers of patients (18/86), and insufficient data (16/86).
CONCLUSIONS: Further high-quality research is necessary to increase the proportion of reviews with clear recommendations. Funding and research agencies are key to selecting the most appropriate research programs.
Yvonne Goda; Harald Sauer; Dominik Schöndorf; Pia Hennes; Ludwig Gortner; Stefan Gräber; Sascha Meyer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-30
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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This article is protected by copyright. All rights reserved.
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