Document Detail


Clinical and radiological presentation of 340 adults with smear-positive tuberculosis in The Gambia.
MedLine Citation:
PMID:  14552563     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SETTING: Four clinics in The Gambia.
OBJECTIVE: To document clinical and radiographic presentations of sputum smear-positive tuberculosis in adults.
DESIGN: Newly diagnosed acid-fast bacilli (AFB) smear, culture-positive tuberculosis patients aged > or = 15 years were interviewed and examined, and underwent tuberculin skin testing, HIV testing and chest X-ray reviewed by a chest physician using set criteria.
RESULTS: Of 340 patients enrolled (median age 29 years; males 73%), 8.3% were HIV-positive. One-third reported haemoptysis, > 90% reported weight loss and fever, and wasting was the most common sign (69%). Crepitations were the most frequent auscultatory finding (41%). The most common radiological lesion was a patchy infiltrate (> 90%). Cavitation was present in 206 patients (60.6%), most frequently occurred in the upper lung fields, was associated with increasing bacterial load in the sputum, and was less prevalent in HIV-positive patients (45% vs. 62%; P = 0.07). Auscultatory and chest X-ray findings matched only one-third of the time.
CONCLUSION: In our setting, wasting is the most common clinical sign of sputum smear-positive tuberculosis. Auscultatory findings correlate poorly with radiological abnormalities. Cavitation is associated with increasing bacterial load in the sputum, and is therefore a strong indicator for early treatment.
Authors:
G Rathman; J Sillah; P C Hill; J F Murray; R Adegbola; T Corrah; C Lienhardt; K P W J McAdam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  7     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-13     Completed Date:  2004-02-24     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  942-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Case-Control Studies
Female
Gambia
Humans
Male
Middle Aged
Sputum / microbiology*
Tuberculin Test
Tuberculosis, Pulmonary / diagnosis*,  microbiology,  radiography*
Grant Support
ID/Acronym/Agency:
MC_U190071468//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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