Document Detail


Clinical and radiological changes during psoriatic arthritis disease progression.
MedLine Citation:
PMID:  12734899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the contribution of radiological findings at the initial visit with respect to classifying patients with psoriatic arthritis (PsA); and to determine the extent to which the clinical disease patterns change over time. METHODS: Patients with PsA were followed prospectively at 6-12 month intervals since 1978; 86 patients were registered within 1 year of diagnosis and were followed for at least 1 year. Based on the clinical information, including the actively inflamed joint count, damaged joint count, and the presence of back disease and arthritis mutilans, a clinical PsA pattern was assigned. A separate radiology pattern based on radiographs alone, and a combined clinical and radiological pattern, was also assigned at each visit. The initial clinical pattern was compared to the initial combined clinical-radiological pattern, and the initial clinical pattern was compared to the clinical pattern at 1 year and 5 years in 35 patients with both 1 and 5 year followup. RESULTS: In 23% of the patients, the radiological assessment in the initial visit showed evidence of patterns not detected clinically; 49% and 77% of the patients showed clinical pattern change within 1 year and 5 years, respectively. A comparison between the group that changed pattern and the one that did not change pattern in 5 years revealed no significant features. CONCLUSION: Radiological assessments add information not gained from clinical assessment alone. Clinical patterns do change over time in the majority of patients. Both elements must be taken into consideration when developing classification criteria for PsA.
Authors:
Mustafa Khan; Catherine Schentag; Dafna D Gladman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  30     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-07     Completed Date:  2003-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1022-6     Citation Subset:  IM    
Affiliation:
University of Toronto Psoriatic Arthritis Clinic, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arthritis, Psoriatic / classification,  radiography*
Disease Progression
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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