Document Detail


Clinical and radiographic correlates of hypoxemia and oxygen therapy in the COPDGene study.
MedLine Citation:
PMID:  21396809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Severe hypoxemia is a major complication of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy is beneficial in hypoxemic COPD patients. However, the clinical and radiographic predictors of hypoxemia and the use of oxygen therapy are not well described. This study aimed to find the correlates of resting hypoxemia and the pattern of oxygen use in moderate to severe COPD patients.
METHODS: Subjects with GOLD stage II or higher COPD from the first 2500 COPDGene subjects were included in this analysis. All subjects were current or ex-smokers between ages 45 and 80. Severe resting hypoxemia was defined as room air oxygen saturation (SpO(2)) ≤88%. Use of supplemental oxygen therapy was determined by questionnaire.
RESULTS: Eighty-two of 1060 COPD subjects (7.7%) had severe resting hypoxemia. Twenty-one of the 82 (25.6%) were not using continuous supplemental oxygen. Female sex, higher BMI, lower FEV(1), and enrollment in Denver were independent risk factors for hypoxemia; emphysema severity on quantitative chest CT scan did not predict hypoxemia. 132 of 971(13.6%) subjects without severe resting hypoxemia were using continuous supplemental oxygen. In non-hypoxemic oxygen users, Denver recruitment, higher BMI, lower FEV(1), and more severe dyspnea were associated with the use of continuous oxygen.
CONCLUSIONS: A large number of COPD patients without severe hypoxemia were using supplemental oxygen therapy and the pattern of oxygen use was affected by factors other than resting SpO(2) and emphysema severity. Longitudinal data will be required to reveal the effects of oxygen therapy in this subgroup. Clinical trial registration: http://clinicaltrials.gov (NCT00608764).
Authors:
Deog Kyeom Kim; Francine L Jacobson; George R Washko; Richard Casaburi; Barry J Make; James D Crapo; Edwin K Silverman; Craig P Hersh
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-10
Journal Detail:
Title:  Respiratory medicine     Volume:  105     ISSN:  1532-3064     ISO Abbreviation:  Respir Med     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-06-17     Completed Date:  2011-09-09     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1211-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00608764
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Anoxia / physiopathology,  radiography,  therapy*
Female
Humans
Male
Middle Aged
Oxygen Inhalation Therapy / utilization*
Practice Guidelines as Topic
Pulmonary Disease, Chronic Obstructive / complications*,  physiopathology,  radiography
Quality of Life
Questionnaires
Rest / physiology
Risk Factors
Severity of Illness Index
Treatment Outcome
Grant Support
ID/Acronym/Agency:
G0701127//Medical Research Council; K08 HL080242-05/HL/NHLBI NIH HHS; K08HL080242/HL/NHLBI NIH HHS; R01 HL094635-02/HL/NHLBI NIH HHS; R01 HL094635-03/HL/NHLBI NIH HHS; R01HL094635/HL/NHLBI NIH HHS; U01 HL089856-01A1/HL/NHLBI NIH HHS; U01 HL089897/HL/NHLBI NIH HHS; U01 HL089897-01A1/HL/NHLBI NIH HHS; U01HL089856/HL/NHLBI NIH HHS; U01HL089897/HL/NHLBI NIH HHS
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