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Clinical proteomics of breast cancer.
MedLine Citation:
PMID:  21532837     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Despite the lifetimes that increased in breast cancers due to the the early screening programs and new therapeutic strategies, many cases still are being lost due to the metastatic relapses. For this reason, new approaches such as the proteomic techniques have currently become the prime objectives of breast cancer researches. Various omic-based techniques have been applied with increasing success to the molecular characterisation of breast tumours, which have resulted in a more detailed classification scheme and have produced clinical diagnostic tests that have been applied to both the prognosis and the prediction of outcome to the treatment. Implementation of the proteomics-based techniques is also seen as crucial if we are to develop a systems biology approach in the discovery of biomarkers of the early diagnosis, prognosis and prediction of the outcome of the breast cancer therapies. In this review, we discuss the studies that have been conducted thus far, for the discovery of diagnostic, prognostic and predictive biomarkers, and evaluate the potential of the discriminating proteins identified in this research for clinical use as breast cancer biomarkers.
Authors:
Y Baskın; T Yiğitbaşı
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current genomics     Volume:  11     ISSN:  1875-5488     ISO Abbreviation:  Curr. Genomics     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100960527     Medline TA:  Curr Genomics     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  528-36     Citation Subset:  -    
Affiliation:
Dokuz Eylul University, Institute of Oncology, 35340 Inciraltı, Izmir, Turkey.
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