| Clinical and prognostic significance of trisomy 21 in adult patients with acute myelogenous leukemia and myelodysplastic syndromes. | |
| | |
MedLine Citation:
|
PMID: 7845005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Trisomy 21 is the second most common trisomy in patients with acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS). However, its clinical and prognostic significance is not known. We analyzed the records of 1187 consecutive patients with untreated AML or MDS. Thirty-seven (3.3%) had trisomy 21: four (0.3%) as the only cytogenetic abnormality and 33 (2.7%) with other cytogenetic abnormalities (-5 and/or -7 in 15, +8 in nine, t(15;17) in three, inv(16) in three, t(8;21) in one, and hyperdiploid with several other additional chromosomes in two). Twenty-eight patients had AML and nine MDS. No patients had megakaryocytic phenotype (M7), common in patients with constitutional trisomy 21 (Down's syndrome) and AML. Overall, 57% achieved complete remission (CR), with median CR duration of 39 weeks, and median survival of 31 weeks. When patients with additional cytogenetic abnormalities were compared to patients with similar abnormalities but no trisomy 21, their clinical features as well as their CR rate, CR duration and survival were similar, with or without trisomy 21. We conclude that trisomy 21 in AML typically presents in conjunction with other cytogenetic abnormalities, especially -5/-7 and +8 whose presence rather than the presence of +21 dictates the clinical outcome. |
| | |
Authors:
|
J E Cortes; H Kantarjian; S O'Brien; M Keating; S Pierce; E J Freireich; E Estey |
Related Documents
:
|
6953605 - Acute leukemia as a transformation after polycythemia vera. 3856835 - Autopsy and clinical findings in acute leukemia and chronic myeloproliferative diseases... 3140655 - Recombinant interferon gamma in hairy cell leukemia, multiple myeloma, and waldenstrom'... 9304705 - Molecular monitoring of residual disease in chronic myelogenous leukemia patients after... 15303045 - Surfer's myelopathy. 14610425 - Postburn galactorrhea with refractory hypertrophic scars: role of obesity under scrutiny. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Leukemia Volume: 9 ISSN: 0887-6924 ISO Abbreviation: Leukemia Publication Date: 1995 Jan |
Date Detail:
|
Created Date: 1995-03-06 Completed Date: 1995-03-06 Revised Date: 2013-03-04 |
Medline Journal Info:
|
Nlm Unique ID: 8704895 Medline TA: Leukemia Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 115-7 Citation Subset: IM |
Affiliation:
|
Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston 77030. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Chromosome Aberrations Down Syndrome / genetics* Female Humans Leukemia, Myeloid, Acute / drug therapy, genetics* Male Middle Aged Myelodysplastic Syndromes / drug therapy, genetics* Prognosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytogenetic clonality in chronic myelomonocytic leukemia studied with fluorescence in situ hybridiza...
Next Document: Phosphorothioate BCR-ABL antisense oligonucleotides induce cell death, but fail to reduce cellular b...