| Clinical profiles of adult patients with single ventricular physiology. | |
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MedLine Citation:
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PMID: 19638711 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study was performed to clarify the present global clinical status, including medication(s) and social abilities, of adult patients with single ventricular physiology (SVP). METHODS AND RESULTS: Clinical charts were retrospectively reviewed to evaluate the global clinical status, including functional capacity, medication(s), complications, and social activities of 68 adult patients with SVP aged 20-53 years (41 males); 50 had undergone the Fontan operation and they were divided into the young adult (25 patients) and adult Fontan groups. The others were cyanotic patients without the Fontan operation (non-Fontan group). Although the Fontan groups showed better functional capacity, higher arterial oxygen saturation and brain natriuretic peptide levels, and a better renal function, there was no difference in the cardiovascular events during follow-up between the 3 groups. The most frequent complication was arrhythmia without a significant group difference, although the non-Fontan group showed a high percentage of heart failure. Only 41 patients (60%) had a job and 8 (12%) were married. CONCLUSIONS: Although the Fontan groups had favorable pathophysiological conditions, the high rate of cardiovascular events, as well as unsatisfactory social situations, indicate the importance of meticulous life-long management of patients with SVP, regardless of the type of surgical intervention. |
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Authors:
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Noriko Motoki; Hideo Ohuchi; Aya Miyazaki; Osamu Yamada |
Publication Detail:
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Type: Journal Article Date: 2009-07-28 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 73 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-26 Completed Date: 2009-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1711-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Arrhythmias, Cardiac / etiology Biological Markers / blood Cardiovascular Agents / therapeutic use* Disease-Free Survival Employment Female Fontan Procedure* / adverse effects, mortality Heart Defects, Congenital / complications, mortality, physiopathology, psychology, therapy* Heart Failure / etiology Heart Ventricles / abnormalities*, physiopathology Hemodynamics Humans Japan Kaplan-Meiers Estimate Male Marital Status Middle Aged Natriuretic Peptide, Brain / blood Palliative Care Quality of Life Retrospective Studies Risk Assessment Survivors* / psychology Time Factors Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cardiovascular Agents; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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