Document Detail

Clinical profiles of adult patients with single ventricular physiology.
MedLine Citation:
PMID:  19638711     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was performed to clarify the present global clinical status, including medication(s) and social abilities, of adult patients with single ventricular physiology (SVP). METHODS AND RESULTS: Clinical charts were retrospectively reviewed to evaluate the global clinical status, including functional capacity, medication(s), complications, and social activities of 68 adult patients with SVP aged 20-53 years (41 males); 50 had undergone the Fontan operation and they were divided into the young adult (25 patients) and adult Fontan groups. The others were cyanotic patients without the Fontan operation (non-Fontan group). Although the Fontan groups showed better functional capacity, higher arterial oxygen saturation and brain natriuretic peptide levels, and a better renal function, there was no difference in the cardiovascular events during follow-up between the 3 groups. The most frequent complication was arrhythmia without a significant group difference, although the non-Fontan group showed a high percentage of heart failure. Only 41 patients (60%) had a job and 8 (12%) were married. CONCLUSIONS: Although the Fontan groups had favorable pathophysiological conditions, the high rate of cardiovascular events, as well as unsatisfactory social situations, indicate the importance of meticulous life-long management of patients with SVP, regardless of the type of surgical intervention.
Noriko Motoki; Hideo Ohuchi; Aya Miyazaki; Osamu Yamada
Publication Detail:
Type:  Journal Article     Date:  2009-07-28
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-26     Completed Date:  2009-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1711-6     Citation Subset:  IM    
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Age Factors
Arrhythmias, Cardiac / etiology
Biological Markers / blood
Cardiovascular Agents / therapeutic use*
Disease-Free Survival
Fontan Procedure* / adverse effects,  mortality
Heart Defects, Congenital / complications,  mortality,  physiopathology,  psychology,  therapy*
Heart Failure / etiology
Heart Ventricles / abnormalities*,  physiopathology
Kaplan-Meiers Estimate
Marital Status
Middle Aged
Natriuretic Peptide, Brain / blood
Palliative Care
Quality of Life
Retrospective Studies
Risk Assessment
Survivors* / psychology
Time Factors
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Cardiovascular Agents; 114471-18-0/Natriuretic Peptide, Brain

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