Document Detail


Clinical profile and treatment outcome of tubercular pleurisy in pediatric age group using DOTS strategy.
MedLine Citation:
PMID:  20469730     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A significant proportion of global tuberculosis (TB) caseload is contributed by children. Management of pediatric TB especially EPTB is challenging. The present study was designed to study demographic, clinical profile and treatment outcome of DOTS strategy for pediatric tubercular pleurisy. AIM: To study the efficacy of DOTS strategy. METHODS: Retrospective analysis of 106 TB pleurisy children treated with DOTS. RESULTS: Mean age was 10.8 years (median age 12.2 years) with more females (51.9%) than males (48.1%) chi1(2) = 0.15; P = 0.698 (NS). In the age group of 0-5, 6-10 and 11-14 years, there were 15.1%, 30.2% and 54.7% patients respectively. Fever was the commonest symptom (98.1%) followed by cough (77.4%) and chest pain (55.7%). History of contact could be elicited only in 2/3rd of cases unilateral effusion (61.3%) was commonest, followed by empyema (22.6%), massive effusion and broncho-pleural fistula each in 13.2% cases respectively. Bilateral effusion was seen in 3.8% cases only. Conventional methods (mantoux, radiograph, ultrasound, pleural aspiration) and minimal invasive surgical techniques, percutaneous pleural biopsy were done to arrive at the diagnosis. Diagnosis was made by X-ray Chest in 92.5%, exudative pleural fluid (100%) predominantly lymphocytic in 85.8%, positive AFB smear and culture in 4.7 and 5.7% cases respectively. Category I, II and III was started on 35.9%, 2.8% and 61.3% patients respectively. Overall treatment completion rate was 94.3%, 4.7% default rate, 0.9% failure rate and no deaths. CONCLUSION: The study confirms early detection by simple tests and ensuring complete treatment using DOTS strategy.
Authors:
Sangeeta Sharma; Rohit Sarin; U K Khalid; N Singla; P P Sharma; D Behera
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Indian journal of tuberculosis     Volume:  56     ISSN:  0019-5707     ISO Abbreviation:  Indian J Tuberc     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373027     Medline TA:  Indian J Tuberc     Country:  India    
Other Details:
Languages:  eng     Pagination:  191-200     Citation Subset:  IM    
Affiliation:
LRS Institute of Tuberculosis and Respiratory Diseases, Sri Aurobindo Marg, New Delhi - 110 030.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antitubercular Agents / therapeutic use
Bronchial Fistula / microbiology
Chest Pain / etiology
Child
Child, Preschool
Cough / etiology
Directly Observed Therapy*
Empyema / microbiology
Female
Fever / etiology
Humans
India
Infant
Infant, Newborn
Male
Pleural Cavity / microbiology
Pleural Effusion / microbiology
Radiography, Thoracic
Retrospective Studies
Sputum / microbiology
Treatment Outcome
Tuberculosis, Pleural / diagnosis*,  drug therapy*
Chemical
Reg. No./Substance:
0/Antitubercular Agents

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