Document Detail


Clinical profile of primary hyperparathyroidism from western India: a single center experience.
MedLine Citation:
PMID:  20622385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Primary hyperparathyroidism (PHPT) has a variable clinical presentation and symptomatic PHPT is still the predominant form of the disease in India. Data from western India is lacking. AIM: To present the clinical profile of PHPT from western India. SETTINGS AND DESIGN: This retrospective study was conducted at a tertiary care referral center. MATERIALS AND METHODS: We analyzed the clinical presentation, biochemical, radiological features, and operative findings in adult patients with PHPT (1986-2008) and compared with our published data of children and adolescent patients with PHPT. STATISTICAL ANALYSIS: was done with SPSS 16 software. RESULTS: Seventy-nine patients (F: M-2:1) with age ranging from 21 to 55 years (mean 33.5+/-8.82) were analyzed. Skeletal manifestations (75.5%), renal calculi (40.5%) and proximal muscle weakness (45.5%) were the most common symptoms of presentation with mean duration of symptoms being 33.70 (median: 24, range 1-120) months. Biochemical features included hypercalcemia (total corrected calcium 12.55+/-1.77 mg/dl), low inorganic phosphorus (1.81+/-0.682 mg/dl), elevated total alkaline phosphatase (mean: 762.2; median: 559; range: 50-4930IU/L) and high parathyroid hormone (PTH) (mean+/-SD: 866.61+/-799.15; median: 639.5; range: 52-3820 pg/ml). Preoperative localization was achieved in 74 patients and single adenoma was found during surgery in 72 patients. Hungry bone disease was seen in 30.3% and transient hypoparathyroidism developed in 62% patients. In comparison to PHPT in children there were no significant differences with regard to clinical, laboratory and radiological features. CONCLUSIONS: PHPT in western India is symptomatic disorder with skeletal and renal manifestations at a much younger age. Clinical profile of PHPT in children is similar to that of adults.
Authors:
R A Gopal; S V Acharya; T Bandgar; P S Menon; A N Dalvi; N S Shah
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of postgraduate medicine     Volume:  56     ISSN:  0022-3859     ISO Abbreviation:  J Postgrad Med     Publication Date:    2010 Apr-Jun
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-09-01     Revised Date:  2010-10-19    
Medline Journal Info:
Nlm Unique ID:  2985196R     Medline TA:  J Postgrad Med     Country:  India    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, KEM Hospital, Parel, Mumbai, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alkaline Phosphatase / blood
Bone Diseases / complications*,  etiology
Calcium / blood*
Female
Humans
Hyperparathyroidism, Primary / blood,  complications*,  surgery
India
Male
Middle Aged
Parathyroid Glands / pathology,  radionuclide imaging,  ultrasonography
Parathyroid Hormone / blood
Parathyroidectomy
Retrospective Studies
Vitamin D Deficiency / complications*
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 7440-70-2/Calcium; EC 3.1.3.1/Alkaline Phosphatase

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