Document Detail

Clinical profile and outcome of first acute myocardial infarction with ischemic mitral regurgitation.
MedLine Citation:
PMID:  18782949     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ischemic mitral regurgitation indicates a poor prognosis after acute myocardial infarction (AMI). This study addresses the clinical characteristics and contribution of ischemic mitral regurgitation to the midterm survival rate of patients following first AMI in our institution. METHODS: Between January 2000 and December 2002, patients who underwent 2-dimensional color Doppler echocardiographic quantitation of ischemic mitral regurgitation within 30 days after first myocardial infarction (MI) were analyzed. RESULTS: During the study period, 519 patients were enrolled (mean age 62.7 +/- 12 years, 76% men). The population was divided into 2 groups based on the degree of mitral regurgitation (MR). Group A included 440 subjects with no MR (n = 41), trivial MR (n = 188), and mild MR (n = 211). Group B included 79 subjects with moderate MR (n = 64), and severe MR (n = 15). Group B patients were more likely to be older (p < 0.05), women (p < 0.01), and nonsmokers (p < 0.01). Group B had a higher prevalence of inferior wall MI (p < 0.01) and lateral wall MI (p < 0.01). After 6 months of follow-up, 57 deaths had occurred (42 in Group A and 15 in Group B). Group B had a lower survival rate than Group A 180 days post-AMI (19% vs. 9.79%, p < 0.01). CONCLUSIONS: Post-AMI patients with significant ischemic mitral regurgitation were more likely to be older, female, and nonsmokers. There was a positive association between the severity of ischemic mitral regurgitation and inferior MI and lateral wall MI. The severity of ischemic mitral regurgitation showed a significant inverse relationship with the mid-term post-MI survival rate.
Sheng-Ying Chung; Fen-Chiung Lin; Sarah Chua; Morgan Fu; Chiung-Jen Wu; Hon-Kan Yip; Kuo-Ho Yeh; Han-Tan Chai; Yuan-Kai Hsieh; Chi-Ling Hang; Chih-Yuan Fang; Shyh-Ming Chen; Cheng-Hsu Yang; Chien-Jen Chen; Fan-Yen Lee; Mien-Cheng Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chang Gung medical journal     Volume:  31     ISSN:  2072-0939     ISO Abbreviation:  Chang Gung Med J     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-09-11     Completed Date:  2008-10-16     Revised Date:  2008-12-16    
Medline Journal Info:
Nlm Unique ID:  101088034     Medline TA:  Chang Gung Med J     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  268-75     Citation Subset:  IM    
Division of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Taiwan, ROC.
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MeSH Terms
Echocardiography, Doppler
Middle Aged
Mitral Valve Insufficiency / complications*
Myocardial Infarction / complications*
Myocardial Ischemia / complications

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