Document Detail

Clinical profile and management of PDA in neonates.
MedLine Citation:
PMID:  10771900     Owner:  NLM     Status:  MEDLINE    
Patent ductus arteriosus (PDA) is recognised more often with increasing survival of preterm babies. The pharmacological closure of ductus by indomethacin has changed the management of PDA. Twenty neonates admitted over a period of 21 months to Neonatal Intensive Care Unit (NICU) of M.S. Ramaiah Medical College hospital, Bangalore, who were diagnosed to have PDA, were analyzed. The objectives of this retrospective analysis were to study the clinical profile, the efficacy of oral indomethacin and the outcome of PDA. 2-D and Doppler echocardiaography were used to confirm the clinically suspected PDA. These neonates were treated with 3 doses of oral indomethacin (0.2-0.25 mg/kg/dose 12 hourly) along with fluid restriction and oxygen. Echocardiography was repeated to demonstrate the closure of PDA. The incidence of PDA was 2.3% of total NICU admissions. Seventy percent of this cohort were < 32 weeks of gestation, 55% had birth weight of < 1500 gms. Seventy percent (14) neonates had onset of PDA after 48 hrs of life. 81.25% of neonates responded to indomethacin and overall survival rate in treated group was 67%. Drug related complications were noted in 2 newborns. This study illustrates the utility of echocardiography in diagnosing and monitoring PDA in preterm and low birth weight babies with high index of suspicion of this common congenital heart disease. Pharmacological intervention with indomethacin is rewarding with acceptable results.
C C Shanthala; P P Maiya; D Vishwanath; N Banakappa; P M Swamy; N Desai; Ravikishore; K H Srinivas
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  64     ISSN:  0019-5456     ISO Abbreviation:  Indian J Pediatr     Publication Date:    1997 Sep-Oct
Date Detail:
Created Date:  2000-05-16     Completed Date:  2000-05-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  667-70     Citation Subset:  IM    
Department of Pediatrics, M.S. Ramaiah Medical College, Bangalore.
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MeSH Terms
Administration, Oral
Cardiovascular Agents / administration & dosage*
Cohort Studies
Dose-Response Relationship, Drug
Ductus Arteriosus, Patent / diagnosis*,  drug therapy*,  mortality
Evaluation Studies as Topic
Indomethacin / administration & dosage*
Infant, Newborn
Infant, Premature, Diseases / drug therapy*,  mortality,  ultrasonography
Intensive Care Units, Neonatal
Retrospective Studies
Survival Rate
Treatment Outcome
Ultrasonography, Doppler
Reg. No./Substance:
0/Cardiovascular Agents; 53-86-1/Indomethacin

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