| Clinical profile of chronic heart failure in elderly women. | |
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MedLine Citation:
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PMID: 12214170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathogenesis, clinical course, and treatment of chronic heart failure (HF) are different in elderly women from those of patients recruited in the landmark trials of chronic HF. Patients included in these landmark trials were predominantly men whose age was 10-15 years younger than the average age of patients with chronic HF in the United States. Diastolic dysfunction resulting in impaired left ventricular (LV) filling is the preponderant LV functional alteration that leads to chronic HF in elderly women. Gender differences in the LV remodeling process that accompanies chronic cardiac pressure are likely to be responsible for the preponderance of LV diastolic dysfunction over systolic dysfunction in elderly women. In response to chronic pressure overload, the LV wall becomes thicker in women than in men. Consequently, in response to chronic pressure overload, women are able to normalize LV wall stress and preserve LV systolic function to a greater extent than men. However, impaired LV filling is an undesirable consequence of the greater increase in LV wall thickness in women. Thus, clinical observations and therapeutic guidelines derived from data collected in the landmark trials of chronic HF may not apply to elderly women with chronic HF. In view of the lack of evidence-based information needed to guide the management of elderly women with chronic HF, special attention should be given to include a substantial number of elderly women in future therapeutic trials recruiting patients with chronic HF. |
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Authors:
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Suman Tandon; Shelley R Hankins; Thierry H Le Jemtel |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of geriatric cardiology Volume: 11 ISSN: 1076-7460 ISO Abbreviation: Am J Geriatr Cardiol Publication Date: 2002 Sep-Oct |
Date Detail:
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Created Date: 2002-09-05 Completed Date: 2002-11-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9215283 Medline TA: Am J Geriatr Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 318-23 Citation Subset: IM |
Copyright Information:
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Copyright 2002 CVRR, Inc. |
Affiliation:
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Department of Medicine, Division of cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Chronic Disease Female Heart Failure / mortality, physiopathology*, therapy* Humans Sex Factors Survival Rate |
| Comments/Corrections | |
Comment In:
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Am J Geriatr Cardiol. 2002 Sep-Oct;11(5):281-2
[PMID:
12214164
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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