Document Detail


Clinical profile of 30 infants with acute pulmonary hemorrhage in Cleveland.
MedLine Citation:
PMID:  12205270     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Between 1993 and 2000, 30 infants were hospitalized with acute pulmonary hemorrhage at Rainbow Babies and Children's Hospital in Cleveland. Most infants presented with severe pulmonary symptoms requiring intensive support, but a few infants had less severe hemorrhage. Three quarters of the patients required ventilator support and blood transfusions. Eleven patients had transitory hemoglobinuria. Five patients died, but infants who survived did well. There are currently no specific treatment modalities, although we have advised moving to a different home and avoiding environmental tobacco smoke. Subsequently, rebleeding from the lower respiratory tract has decreased from 5 of 7 infants to 1 in 21. On the basis of decreased subsequent fatal hemorrhage, high dose glucocorticoids seem to be of some value. Several patients revealed continued low-grade alveolar hemorrhage for months after their initial bleed, even after removal from their original home environments.
Authors:
Dorr G Dearborn; Paul G Smith; Beverly B Dahms; Terrence M Allan; W G Sorenson; Eduardo Montana; Ruth A Etzel
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  110     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-02     Completed Date:  2002-10-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  627-37     Citation Subset:  AIM; IM    
Affiliation:
Pediatric Pulmonary Division, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio 44106-5000, USA. dxd9@po.cwru.edu
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Cluster Analysis
Diseases in Twins
Environmental Exposure / adverse effects*
Fatal Outcome
Female
Hemorrhage / epidemiology*,  etiology,  physiopathology,  therapy
Hemosiderosis / epidemiology*,  physiopathology,  therapy
Humans
Infant
Lung Diseases / epidemiology*,  etiology,  physiopathology,  therapy
Male
Ohio / epidemiology
Risk Factors
Severity of Illness Index
Stachybotrys*
Tobacco Smoke Pollution / adverse effects*
Grant Support
ID/Acronym/Agency:
ES08549/ES/NIEHS NIH HHS; ES09742/ES/NIEHS NIH HHS; M01 RR00080/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Tobacco Smoke Pollution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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