Document Detail

Clinical presentation of parvovirus B19 infection in children with aplastic crisis.
MedLine Citation:
PMID:  14688575     Owner:  NLM     Status:  MEDLINE    
The records of 22 children with parvovirus B19-induced aplastic crisis were reviewed. The group consisted of 16 children with sickle cell hemoglobinopathies and 6 with hereditary spherocytosis. Children presented to the hospital 0.5 to 8 days (mean, 2.4 days) after the onset of symptoms. The children with sickle-cell disease presented earlier (mean, 1.4 days) than did children with hereditary spherocytosis (mean, 5 days; P = 0.02. Fever was the most common symptom, occurring in 73% of children. Rash did not occur in either group. Reticulocyte counts began to rise 1 week after onset of illness associated with a rise in parvovirus B19-specific IgG antibody. These data suggest that parvovirus B19 infection in children with sickle-cell hemoglobinopathies and heredity spherocytosis differs from infection in normal children.
Richard Kellermayer; Howard Faden; Mauro Grossi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  22     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1100-1     Citation Subset:  IM    
School of Medicine and Biomedical Sciences, State University of New York at Buffalo, The Children's Hospital of Buffalo, USA.
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MeSH Terms
Anemia, Aplastic / etiology*,  physiopathology*
Anemia, Sickle Cell / complications*,  diagnosis
Case-Control Studies
Child, Preschool
Erythema Infectiosum / complications*,  diagnosis
Follow-Up Studies
Parvovirus B19, Human / isolation & purification*
Reference Values
Retrospective Studies
Risk Assessment
Severity of Illness Index
Spherocytosis, Hereditary / complications*,  diagnosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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