Document Detail

Clinical presentation and outcome of colorectal cancer in HIV-positive patients: a clinical case-control study.
MedLine Citation:
PMID:  19521118     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Data on colorectal cancer (CRC) in HIV-positive patients are limited. The study objective was to investigate and compare clinical presentation and outcome between HIV-positive and HIV-negative CRC patients. PATIENTS AND METHODS: Between September 1985 and November 2003 we identified 27 cases of HIV-positive CRC patients from the cancer registry database - Italian Cooperative Group AIDS and Tumours (GICAT); the clinical presentation/outcome information was retrieved. Each HIV-positive patient from our institution was randomly matched (ratio 1:2) with HIV-negative patients (54 controls) based on age, sex, and year of diagnosis in the same time period. Differences in clinical presentation, treatment, and overall survival were assessed. RESULTS: Of 1130 HIV-negative CRC patients, 54 were identified and matched with 27 HIV-positive patients. Compared with the HIV-negative patients, the HIV-positive patients had a higher risk of lower performance status (PS: > or =2) (odds ratio (OR) = 14.4; 95% confidence interval (CI): 3.6-57.7), a higher risk of unfavorable Dukes' stage (D) (OR = 4.9; 95% CI: 1.8-13.5), and a higher risk of poor grading (G3-G4) (OR = 5.0; 95% CI: 1.9-13.4). Median overall follow-up was 27 months (range: 2-212). At multivariate analysis, the only characteristics that significantly reduced the survival of the CRC patients were: HIV-positive status (hazard ratio (HR): 2.4; 95% CI: 1.1-5.2) and Dukes' stage D (HR: 3.7; 95% CI: 1.9-7.1). CONCLUSION: Our data show that HIV-positive CRC patients compared to HIV-negative patients have a poorer PS, an unfavorable Dukes' stage, higher grading and shorter survival.
Massimiliano Berretta; Alessandro Cappellani; Fabrizio Di Benedetto; Arben Lleshi; Renato Talamini; Vincenzo Canzonieri; Ernesto Zanet; Alessandra Bearz; Guglielmo Nasti; Teresa Lacchin; Salvatore Berretta; Rossella Fisichella; Luca Balestreri; Augusta Torresin; Immacolata Izzi; Patrizia Ortolani; Umberto Tirelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-14
Journal Detail:
Title:  Onkologie     Volume:  32     ISSN:  1423-0240     ISO Abbreviation:  Onkologie     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-12     Completed Date:  2009-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7808556     Medline TA:  Onkologie     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  319-24     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Division of Medical Oncology A, National Cancer Institute, Aviano, Italy.
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MeSH Terms
Case-Control Studies
Colorectal Neoplasms / mortality*
HIV Infections / mortality*
Italy / epidemiology
Middle Aged
Outcome Assessment (Health Care)
Risk Assessment
Risk Factors
Survival Analysis
Survival Rate
Comment In:
Onkologie. 2009 Jun;32(6):306-7   [PMID:  19521115 ]

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