Document Detail

Clinical presentation and natural history of patients with essential thrombocythemia and the Philadelphia chromosome.
MedLine Citation:
PMID:  3422539     Owner:  NLM     Status:  MEDLINE    
Six women presented with the clinical picture of essential thrombocythemia (ET) without the anemia, marked splenomegaly, and extreme leukocytosis characteristic of chronic myelogenous leukemia (CML). All had the Philadelphia chromosome on karyotype analysis of the bone marrow. Peripheral basophilia was present in four cases, providing a clinical clue that the Philadelphia chromosome might be present. Marrow biopsy showed granulocytic hyperplasia and either small megakaryocytes or sheets of megakaryocytes with marked atypia, findings that are more typical of CML than ET. The clinical importance of finding the Philadelphia chromosome in patients who seem to have ET is in assessing prognosis. ET generally follows a chronic, indolent course. However, five of these six patients who had the Philadelphia chromosome underwent clinical transition to the accelerated phase of CML or blastic leukemia in 4-7 years.
D B Stoll; P Peterson; R Exten; J Laszlo; A V Pisciotta; J T Ellis; P White; K Vaidya; M Bozdech; S Murphy
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hematology     Volume:  27     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-08     Completed Date:  1988-03-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-83     Citation Subset:  IM    
Cardeza Foundation for Hematologic Research, Philadelphia, PA 19107.
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MeSH Terms
Bone Marrow / pathology
Leukemia, Myeloid / pathology
Megakaryocytes / pathology
Middle Aged
Philadelphia Chromosome*
Thrombocythemia, Essential / genetics,  pathology*
Grant Support

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