| Clinical presentation, management, and outcomes of angiographically documented early, late, and very late stent thrombosis. | |
| | |
MedLine Citation:
|
PMID: 22361596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: The aim of this study was to describe differences in treatment and in-hospital mortality of early, late, and very late stent thrombosis (ST). BACKGROUND: Early, late, and very late ST may differ in clinical presentation, management, and in-hospital outcomes. METHODS: We analyzed definite (angiographically documented) ST cases identified from February 2009 to June 2010 in the CathPCI Registry. We stratified events by timing of presentation: early (≤1 month), late (1 to 12 months), or very late (≥12 months) following stent implantation. Multivariable logistic regression modeling was performed to compare in-hospital mortality for each type of ST after adjusting for baseline comorbidities. RESULTS: During the study period, 7,315 ST events were identified in 7,079 of 401,662 patients (1.8%) presenting with acute coronary syndromes. This ST cohort consisted of 1,391 patients with early ST (19.6%), 1,370 with late ST (19.4%), and 4,318 with very late ST (61.0%). Subjects with early ST had a higher prevalence of black race and diabetes, whereas subjects with very late ST had a higher prevalence of white race and a lower prevalence of prior myocardial infarction or diabetes. In-hospital mortality was significantly higher in early ST (7.9%) compared with late (3.8%) and very late ST (3.6%, p<0.001). This lower mortality for late and very late ST persisted after multivariable adjustment (odds ratio: 0.53 [95% confidence interval (CI): 0.36 to 0.79] and 0.58 [95% CI: 0.43 to 0.79], respectively). CONCLUSIONS: Significant differences exist in the presentation and outcomes of early, late, and very late ST. Among patients with acute coronary syndromes who are undergoing percutaneous coronary intervention for angiographically documented ST, early ST is associated with the highest in-hospital mortality. |
| | |
Authors:
|
Ehrin J Armstrong; Dmitriy N Feldman; Tracy Y Wang; Lisa A Kaltenbach; Khung-Keong Yeo; S Chiu Wong; John Spertus; Richard E Shaw; Robert M Minutello; Issam Moussa; Kalon K L Ho; Jason H Rogers; Kendrick A Shunk |
Related Documents
:
|
17466396 - Acute myocardial infarction from simultaneous total occlusion of the left circumflex an... 20538116 - Clinical and angiographic predictors of st-segment recovery after primary percutaneous ... 9771316 - Myocardial ischaemia during tracheal extubation in patients after cardiac surgery: an o... 9290136 - The study of steady magnetic fields associated with primary and secondary st shift in i... 8076096 - Prophylactic myocardial revascularization based on dipyridamole-thallium scanning befor... 19164336 - Refining the assessment of pulmonary regurgitation in adults after tetralogy of fallot ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: JACC. Cardiovascular interventions Volume: 5 ISSN: 1876-7605 ISO Abbreviation: JACC Cardiovasc Interv Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-02-24 Completed Date: 2012-07-09 Revised Date: 2012-08-29 |
Medline Journal Info:
|
Nlm Unique ID: 101467004 Medline TA: JACC Cardiovasc Interv Country: United States |
Other Details:
|
Languages: eng Pagination: 131-40 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Cardiology, University of California, Davis Medical Center, Sacramento, California 95817, USA. ehrin.armstrong@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angioplasty, Balloon, Coronary / instrumentation Confidence Intervals Coronary Angiography / instrumentation* Coronary Thrombosis / mortality*, therapy Drug-Eluting Stents* Female Hospital Mortality / trends Humans Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Registries Risk Assessment Time Factors Treatment Outcome United States |
| Comments/Corrections | |
Comment In:
|
JACC Cardiovasc Interv. 2012 Feb;5(2):141-4
[PMID:
22361597
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Principles of percutaneous paravalvular leak closure.
Next Document: Long-term comparison of everolimus- and sirolimus-eluting stents in patients with acute coronary syn...