|Clinical presentation and management of Fasciola hepatica infection: single-center experience.|
|PMID: 22171131 Owner: NLM Status: MEDLINE|
|AIM: To identify the characteristic clinical, laboratory and radiological findings and response to treatment in patients with fascioliasis.
METHODS: Patients who were diagnosed with Fasciola hepatica infection were included in this prospective study. Initial clinical, laboratory and radiological findings were recorded. All patients were followed until a complete response was achieved or for 6 mo after treatment discontinuation.
RESULTS: Fasciola hepatica infection was diagnosed in 30 patients (24 females; mean age: 42.6 years) between January 2008 and February 2011. Twenty-two (73%) patients had hepatic phase fascioliasis, 5 patients had biliary phase, and 3 patients had biliary phase associated with acute pancreatitis. Of the 8 patients with biliary phase fascioliasis, 2 patients displayed features that overlapped with both hepatic and biliary phase. Abdominal pain and right upper abdominal tenderness were the most prominent signs and symptoms in all patients. Eosinophilia was the most prominent laboratory abnormality in both patients with hepatic and biliary phase (100% and 50%, respectively). Multiple nodular lesions like micro-abscesses on abdominal computerized tomography were the main radiological findings in patients with hepatic phase. Small linear filling defects in the distal choledochus were the main endoscopic retrograde cholangiopancreatography (ERCP) findings in patients with biliary phase. Patients with hepatic phase were treated with triclabendazole alone, and patients with biliary phase were treated with triclabendazole and had live Fasciola hepatica extracted from the bile ducts during ERCP.
CONCLUSION: Fasciola hepatica infection should be considered in the differential diagnosis of patients with hepatic or biliary disease and/or acute pancreatitis associated with eosinophilia.
|Muhsin Kaya; Remzi Beştaş; Sedat Cetin|
|Type: Journal Article|
|Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 2219-2840 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Nov|
|Created Date: 2011-12-15 Completed Date: 2012-02-24 Revised Date: 2014-05-20|
Medline Journal Info:
|Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China|
|Languages: eng Pagination: 4899-904 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Anthelmintics / therapeutic use
Benzimidazoles / therapeutic use
Bile Ducts / parasitology, pathology
Fascioliasis / drug therapy, pathology*, physiopathology*, radiography
Liver / parasitology*, pathology*, radiography
Tomography, X-Ray Computed
|0/Anthelmintics; 0/Benzimidazoles; 68786-66-3/triclabendazole|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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