Document Detail


Clinical presentation and management of Fasciola hepatica infection: single-center experience.
MedLine Citation:
PMID:  22171131     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To identify the characteristic clinical, laboratory and radiological findings and response to treatment in patients with fascioliasis.
METHODS: Patients who were diagnosed with Fasciola hepatica infection were included in this prospective study. Initial clinical, laboratory and radiological findings were recorded. All patients were followed until a complete response was achieved or for 6 mo after treatment discontinuation.
RESULTS: Fasciola hepatica infection was diagnosed in 30 patients (24 females; mean age: 42.6 years) between January 2008 and February 2011. Twenty-two (73%) patients had hepatic phase fascioliasis, 5 patients had biliary phase, and 3 patients had biliary phase associated with acute pancreatitis. Of the 8 patients with biliary phase fascioliasis, 2 patients displayed features that overlapped with both hepatic and biliary phase. Abdominal pain and right upper abdominal tenderness were the most prominent signs and symptoms in all patients. Eosinophilia was the most prominent laboratory abnormality in both patients with hepatic and biliary phase (100% and 50%, respectively). Multiple nodular lesions like micro-abscesses on abdominal computerized tomography were the main radiological findings in patients with hepatic phase. Small linear filling defects in the distal choledochus were the main endoscopic retrograde cholangiopancreatography (ERCP) findings in patients with biliary phase. Patients with hepatic phase were treated with triclabendazole alone, and patients with biliary phase were treated with triclabendazole and had live Fasciola hepatica extracted from the bile ducts during ERCP.
CONCLUSION: Fasciola hepatica infection should be considered in the differential diagnosis of patients with hepatic or biliary disease and/or acute pancreatitis associated with eosinophilia.
Authors:
Muhsin Kaya; Remzi Beştaş; Sedat Cetin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-15     Completed Date:  2012-02-24     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4899-904     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Dicle University School of Medicine, Diyarbakır 21280, Turkey. muhsinkaya20@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Abdominal Pain / parasitology,  pathology,  physiopathology,  radiography
Adult
Aged
Animals
Anthelmintics / therapeutic use
Benzimidazoles / therapeutic use
Bile Ducts / parasitology,  pathology
Diagnosis, Differential
Disease Management
Fasciola hepatica
Fascioliasis / drug therapy,  pathology*,  physiopathology*,  radiography
Female
Humans
Liver / parasitology*,  pathology*,  radiography
Male
Middle Aged
Prospective Studies
Tomography, X-Ray Computed
Young Adult
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Benzimidazoles; 68786-66-3/triclabendazole
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