Document Detail


Clinical pregnancy after uterus transplantation.
MedLine Citation:
PMID:  23830110     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To present the first clinical pregnancy after uterus transplantation.
DESIGN: Case study.
SETTING: Tertiary center.
PATIENT(S): A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation.
INTERVENTION(S): Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos.
MAIN OUTCOME MEASURE(S): Implantation of embryo in an allografted human uterus.
RESULT(S): The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization.
CONCLUSION(S): We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.
Authors:
Munire Erman Akar; Omer Ozkan; Batu Aydinuraz; Kerem Dirican; Mehmet Cincik; Inanc Mendilcioglu; Mehmet Simsek; Filiz Gunseren; Huseyin Kocak; Akif Ciftcioglu; Omer Gecici; Ozlenen Ozkan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-3
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey. Electronic address: meakar@akdeniz.edu.tr.
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