Document Detail

Clinical predictors of drug response in obsessive-compulsive disorder.
MedLine Citation:
PMID:  11593074     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate which clinical variables might influence the antiobsessional response to proserotonergic drugs in a sample of patients with obsessive-compulsive disorder (OCD). One hundred fifty-nine patients with DSM-IV OCD underwent a 12-week standardized treatment with fluvoxamine, clomipramine, citalopram, or paroxetine. According to treatment response, defined as a reduction of the Yale-Brown Obsessive Compulsive Scale total score >35%, patients were divided into two groups. Ninety patients (56.6%) responded to treatment and 69 (43.4%) did not. Responders had a significantly higher frequency of positive family history for OCD (FH-OCD) in their first-degree relatives, whereas nonresponders had an earlier onset and a higher frequency of "poor insight" subtype and somatic obsessions. The predictive value of all these variables was tested by a stepwise logistic regression analysis that confirmed poor insight and FH-OCD to be the best predictors of poor and good drug treatment response, respectively. These preliminary findings need additional investigations toward a better definition of the genetic and biological heterogeneity of patients with OCD, and they underlie the importance of collecting the insight score and family history for psychiatric disorders in the pretreatment assessment.
S Erzegovesi; M C Cavallini; P Cavedini; G Diaferia; M Locatelli; L Bellodi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  21     ISSN:  0271-0749     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-12     Completed Date:  2002-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  488-92     Citation Subset:  IM    
Department of Neuropsychiatric Sciences, S. Raffaele Hospital, University of Milan School of Medicine, Milano, Italy.
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MeSH Terms
Analysis of Variance
Citalopram / therapeutic use*
Clomipramine / therapeutic use*
Drug Resistance / genetics*
Fluvoxamine / therapeutic use*
Middle Aged
Obsessive-Compulsive Disorder / drug therapy*,  genetics
Paroxetine / therapeutic use*
Predictive Value of Tests
Psychological Tests
Random Allocation
Regression Analysis
Serotonin Uptake Inhibitors / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 303-49-1/Clomipramine; 54739-18-3/Fluvoxamine; 59729-33-8/Citalopram; 61869-08-7/Paroxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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