| Clinical predictors of drug response in obsessive-compulsive disorder. | |
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MedLine Citation:
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PMID: 11593074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate which clinical variables might influence the antiobsessional response to proserotonergic drugs in a sample of patients with obsessive-compulsive disorder (OCD). One hundred fifty-nine patients with DSM-IV OCD underwent a 12-week standardized treatment with fluvoxamine, clomipramine, citalopram, or paroxetine. According to treatment response, defined as a reduction of the Yale-Brown Obsessive Compulsive Scale total score >35%, patients were divided into two groups. Ninety patients (56.6%) responded to treatment and 69 (43.4%) did not. Responders had a significantly higher frequency of positive family history for OCD (FH-OCD) in their first-degree relatives, whereas nonresponders had an earlier onset and a higher frequency of "poor insight" subtype and somatic obsessions. The predictive value of all these variables was tested by a stepwise logistic regression analysis that confirmed poor insight and FH-OCD to be the best predictors of poor and good drug treatment response, respectively. These preliminary findings need additional investigations toward a better definition of the genetic and biological heterogeneity of patients with OCD, and they underlie the importance of collecting the insight score and family history for psychiatric disorders in the pretreatment assessment. |
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Authors:
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S Erzegovesi; M C Cavallini; P Cavedini; G Diaferia; M Locatelli; L Bellodi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical psychopharmacology Volume: 21 ISSN: 0271-0749 ISO Abbreviation: J Clin Psychopharmacol Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-12 Completed Date: 2002-01-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8109496 Medline TA: J Clin Psychopharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 488-92 Citation Subset: IM |
Affiliation:
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Department of Neuropsychiatric Sciences, S. Raffaele Hospital, University of Milan School of Medicine, Milano, Italy. erzegovesi.stefano@hsr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Analysis of Variance Citalopram / therapeutic use* Clomipramine / therapeutic use* Drug Resistance / genetics* Female Fluvoxamine / therapeutic use* Humans Male Middle Aged Obsessive-Compulsive Disorder / drug therapy*, genetics Paroxetine / therapeutic use* Predictive Value of Tests Psychological Tests Random Allocation Regression Analysis Serotonin Uptake Inhibitors / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Uptake Inhibitors; 303-49-1/Clomipramine; 54739-18-3/Fluvoxamine; 59729-33-8/Citalopram; 61869-08-7/Paroxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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