Document Detail

Clinical and polysomnographic predictors of the natural history of poor sleep in the general population.
MedLine Citation:
PMID:  22547895     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: Approximately 8-10% of the general population suffers from chronic insomnia, whereas another 20-30% of the population has insomnia symptoms at any given time (i.e., poor sleep). However, few longitudinal studies have examined risk factors of the natural history of poor sleep, and none have examined the role of polysomnographic (PSG) variables.
DESIGN: Representative longitudinal study.
SETTING: Sleep laboratory.
PARTICIPANTS: From a random, general population sample of 1,741 individuals of the adult Penn State Cohort, 1,395 were followed up after 7.5 yr.
MEASUREMENTS: Full medical evaluation and 1-night PSG at baseline and telephone interview at follow-up.
RESULTS: The rate of incident poor sleep was 18.4%. Physical (e.g., obesity, sleep apnea, and ulcer) and mental (e.g., depression) health conditions and behavioral factors (e.g., smoking and alcohol consumption) increased the odds of incident poor sleep as compared to normal sleep. The rates of persistent, remitted, and poor sleepers who developed chronic insomnia were 39%, 44%, and 17%, respectively. Risk factors for persistent poor sleep were physical health conditions combined with psychologic distress. Shorter objective sleep duration and a family history of sleep problems were risk factors for poor sleep evolving into chronic insomnia.
CONCLUSIONS: Poor sleep appears to be primarily a symptom of physical and mental health conditions, whereas the persistence of poor sleep is associated with psychologic distress. Importantly, sleep apnea appears to be associated with incident poor sleep but not with chronic insomnia. Finally, this study suggests that objective short sleep duration in poor sleepers is a biologic marker of genetic predisposition to chronic insomnia.
Julio Fernandez-Mendoza; Alexandros N Vgontzas; Edward O Bixler; Ravi Singareddy; Michele L Shaffer; Susan L Calhoun; Maria Karataraki; Antonio Vela-Bueno; Duanping Liao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-05-01
Journal Detail:
Title:  Sleep     Volume:  35     ISSN:  1550-9109     ISO Abbreviation:  Sleep     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-01     Completed Date:  2012-09-05     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  689-97     Citation Subset:  IM    
Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA, USA.
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MeSH Terms
Health Status
Longitudinal Studies
Mental Health
Middle Aged
Sleep / physiology
Sleep Initiation and Maintenance Disorders / etiology*,  physiopathology
Young Adult
Grant Support
R01 40916//PHS HHS; R01 51931//PHS HHS; R0164415//PHS HHS

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