| Clinical pharmacology and pharmacogenetics in a genomics era: the DMET platform. | |
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MedLine Citation:
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PMID: 20017675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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While no genome-wide pharmacogenetics study has yet been published, the field of pharmacogenetics is moving towards exploratory, large-scale analyses of the interaction between genetic variation and drug treatment. The Drug Metabolizing Enzymes and Transporters (DMET) platform offers a standardized set of 1936 variants in 225 genes related to drug absorption, distribution, metabolism and elimination that is useful to scan the genome for previously unknown associations between variation in absorption, distribution, metabolism and elimination genes and pharmacokinetic and pharmacodynamic outcomes of drug treatment. The purpose of this review is to put the DMET platform into context within the current study designs that have been used in pharmacogenetics, and to explore the role that DMET has played - and will play - in future pharmacogenetics studies. |
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Authors:
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Tristan M Sissung; Bevin C English; David Venzon; William D Figg; John F Deeken |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review |
Journal Detail:
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Title: Pharmacogenomics Volume: 11 ISSN: 1744-8042 ISO Abbreviation: Pharmacogenomics Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-18 Completed Date: 2010-03-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897350 Medline TA: Pharmacogenomics Country: England |
Other Details:
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Languages: eng Pagination: 89-103 Citation Subset: IM |
Affiliation:
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National Cancer Institute, Bethesda, MD 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Databases, Factual* Enzymes Genes Genome-Wide Association Study Humans Individualized Medicine Pharmaceutical Preparations / metabolism Pharmacogenetics* / methods Pharmacology, Clinical* / methods |
| Chemical | |
Reg. No./Substance:
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0/Enzymes; 0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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