Document Detail


Clinical pharmacology of pancreatic enzymes in patients with cystic fibrosis and in vitro performance of microencapsulated formulations.
MedLine Citation:
PMID:  8163716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Improving protein and fat absorption in patients with cystic fibrosis relates to the amount of biologically active enzyme reaching the duodenum. Microencapsulated formulations are more effective than conventional products but differ in content, ability to retard acid inactivation and the pH at which they release enzymes. Contaminants in these products contribute to hyperuricosuria.
Authors:
M Kraisinger; G Hochhaus; A Stecenko; E Bowser; L Hendeles
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  34     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-05-26     Completed Date:  1994-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  158-66     Citation Subset:  IM    
Affiliation:
Department of Pharmacy Services, Shands Hospital, Gainesville, Florida.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Chemistry, Pharmaceutical
Child
Child, Preschool
Cystic Fibrosis / complications,  drug therapy*,  physiopathology
Exocrine Pancreatic Insufficiency / drug therapy*,  etiology,  physiopathology
Humans
Intestinal Absorption
Lipase / metabolism
Microspheres
Pancreas / enzymology,  physiopathology
Pancreatin / administration & dosage,  pharmacology,  therapeutic use*
Grant Support
ID/Acronym/Agency:
MO1RR00082/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
8049-47-6/Pancreatin; EC 3.1.1.3/Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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