Document Detail


Clinical pharmacology of mivacurium in pediatric patients less than off years old during nitrous oxide-halothane anesthesia.
MedLine Citation:
PMID:  8214654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined the dose-response relationship of mivacurium in infants 2-6 and 7-11 mo of age during nitrous oxide-halothane anesthesia. The neuromuscular and cardiovascular effects of a bolus dose of mivacurium larger than the ED95 in infants and young children from 2-23 mo of age were observed. The infusion rate of mivacurium required to maintain approximately 95% neuromuscular block was determined. There was no significant difference between the estimated dose-response relationship in infants 2-6 mo and that in infants 7-11 mo. The ED50 and ED95 were 44 micrograms/kg and 85 micrograms/kg for infants 2-11 mo (n = 70), r = 0.53. A bolus dose of 150 micrograms/kg mivacurium in infants (2-6 mo) produced 100% depression of the initial twitch height (T1) in 8 out of 9 infants and 85% depression in 1 infant. The time to onset of maximum block was 1.6 +/- 0.3 (0.7-2.7) (mean, SEM [range]) min, and time to recovery to 25% of T1 (T25) was 7.5 +/- 0.7 (5.5-11) min after 150 micrograms/kg in these patients. A bolus dose of 200 micrograms/kg mivacurium in infants and young children (7-23 mo) produced 100% depression of T1 in 14 of 17 patients, 97% depression in 2, and 90% depression in 1. The time to onset of maximum block was 1.5 +/- 0.1 (0.8-3) min and T25 was 10.3 +/- 1.5 (4.8-30.5) min after 200 micrograms/kg in these patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
S K Woelfel; B W Brandom; F X McGowan; D R Cook
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  77     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-10-28     Completed Date:  1993-10-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  713-20     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, Children's Hospital of Pittsburgh, PA 15213-2583.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Inhalation*
Cholinesterases / blood
Dose-Response Relationship, Drug
Halothane*
Hemodynamics / drug effects
Humans
Infant
Infusions, Intravenous
Isoquinolines / administration & dosage,  pharmacology*
Neuromuscular Depolarizing Agents / administration & dosage,  pharmacology*
Neuromuscular Junction / drug effects
Nitrous Oxide*
Chemical
Reg. No./Substance:
0/Isoquinolines; 0/Neuromuscular Depolarizing Agents; 10024-97-2/Nitrous Oxide; 106791-40-6/mivacurium; 151-67-7/Halothane; EC 3.1.1.8/Cholinesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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