Document Detail


Clinical pharmacology of hexachlorophene in newborn infants.
MedLine Citation:
PMID:  894425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bathing with soap containing hexachlorophene was instituted during two major staphylococcal epidemics in a Neonatal Intensive Care Unit. Infants who weighed less than 1,200 gm, those with a postconceptional age of less than 35 weeks, and those with large areas of abraded skin were at highest risk to achieve elevated blood HCP concentrations. T 1/2 of HCP ranged from 6.1 to 44.2 hours and appeared to follow first order kinetics. Time of peak blood concentrations of HCP following a bath ranged from 6 to 10 hours. One infant with liver disease achieved a concentration of HCP of 4,350 ng/ml after seven baths and developed clinical symptoms consistent with HCP toxicity.
Authors:
E E Tyrala; L S Hillman; R E Hillman; W E Dodson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  91     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-10-20     Completed Date:  1977-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Autopsy
Baths
Birth Weight
Disease Outbreaks / prevention & control
Female
Gestational Age
Half-Life
Hexachlorophene / adverse effects,  metabolism*
Humans
Infant, Newborn*
Infant, Newborn, Diseases / prevention & control
Intensive Care Units
Kinetics
Liver Diseases / etiology
Nurseries, Hospital
Staphylococcal Infections / prevention & control
Chemical
Reg. No./Substance:
70-30-4/Hexachlorophene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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