| Clinical pharmacology of hexachlorophene in newborn infants. | |
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MedLine Citation:
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PMID: 894425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bathing with soap containing hexachlorophene was instituted during two major staphylococcal epidemics in a Neonatal Intensive Care Unit. Infants who weighed less than 1,200 gm, those with a postconceptional age of less than 35 weeks, and those with large areas of abraded skin were at highest risk to achieve elevated blood HCP concentrations. T 1/2 of HCP ranged from 6.1 to 44.2 hours and appeared to follow first order kinetics. Time of peak blood concentrations of HCP following a bath ranged from 6 to 10 hours. One infant with liver disease achieved a concentration of HCP of 4,350 ng/ml after seven baths and developed clinical symptoms consistent with HCP toxicity. |
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Authors:
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E E Tyrala; L S Hillman; R E Hillman; W E Dodson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pediatrics Volume: 91 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1977 Sep |
Date Detail:
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Created Date: 1977-10-20 Completed Date: 1977-10-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 481-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autopsy Baths Birth Weight Disease Outbreaks / prevention & control Female Gestational Age Half-Life Hexachlorophene / adverse effects, metabolism* Humans Infant, Newborn* Infant, Newborn, Diseases / prevention & control Intensive Care Units Kinetics Liver Diseases / etiology Nurseries, Hospital Staphylococcal Infections / prevention & control |
| Chemical | |
Reg. No./Substance:
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70-30-4/Hexachlorophene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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