| Clinical pharmacology of antihypertensive therapy. | |
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MedLine Citation:
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PMID: 16202694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adequate control of blood pressure poses challenges for hypertensive patients and their physicians. Success rates of greater than 80% in reducing blood pressure to target values among high-risk hypertensive patients reported by several recent clinical trials argue that effective medications currently are available. Yet, only 34% of hypertensive patients in the United States are at their goal blood pressure according to the most recent national survey. Rational selection of antihypertensive drugs that target both the patient's blood pressure and comorbid conditions coupled with more frequent use of low-dose drug combinations that have additive efficacy and low adverse-effect profiles could improve significantly US blood pressure control rates and have a positive impact on hypertension-related cardiovascular and renal mortality and morbidity. This article reviews the pharmacokinetic and pharmacodynamic principles that underlie the actions of drugs in each of the classes of antihypertensive agents when used alone and in combination, provides practical pharmacologic information about the drugs most frequently prescribed for treatment of hypertension in the outpatient setting, and summarizes the current data influencing the selection of drugs that might be used most effectively in combination for the majority of hypertensive patients whose blood pressures are not controlled adequately by single-drug therapy. |
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Authors:
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Addison A Taylor; James L Pool |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in nephrology Volume: 25 ISSN: 0270-9295 ISO Abbreviation: Semin. Nephrol. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-10-05 Completed Date: 2005-11-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 215-26 Citation Subset: IM |
Affiliation:
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Section on Hypertension and Clinical Pharmacology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. ataylor@bcm.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Drug Therapy, Combination Humans Hypertension / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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