Document Detail


Clinical pharmacological evaluation of calcium antagonists and other drugs modifying myogenic tone in essential hypertension.
MedLine Citation:
PMID:  2681593     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The factors determining the acute and long-term response to calcium antagonists have been studied in controlled trials in essential hypertension. The importance of dose and plasma level in determining the response has been confirmed. The blood pressure response has been modelled and mathematically described, with drug concentrations related to blood pressure falls by linear or Emax (maximum fall in blood pressure) models. The acute response predicted the response after 6 weeks of treatment. Neither age nor plasma renin activity independently influenced the response to calcium antagonists. The level of pretreatment blood pressure (starting blood pressure) was positively related to indices of response. In similar studies with other drugs modifying myogenic tone, while vascular reactivity to selective agonists was reduced, enhanced or unchanged, blood pressure falls were related to plasma levels in all cases.
Authors:
J L Reid; R Donnelly; P A Meredith; H L Elliott
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  7     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-12-20     Completed Date:  1989-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S169-71     Citation Subset:  IM    
Affiliation:
Department of Materia Medica, Stobhill General Hospital, Glasgow, UK.
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure
Calcium Channel Blockers / blood,  pharmacology*
Evaluation Studies as Topic
Humans
Hypertension / physiopathology*
Muscle Tonus / drug effects*
Pressoreceptors / physiology
Randomized Controlled Trials as Topic
Statistics as Topic
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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