| Clinical pharmacokinetics of the newer benzodiazepines. | |
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MedLine Citation:
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PMID: 6133664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New benzodiazepine derivatives continue to be developed and introduced into clinical use. The pharmacokinetic properties of these newer drugs can best be understood by their categorisation according to range of elimination half-life and pathway of metabolism (oxidation versus conjugation). Clobazam and halazepam are long half-life (and therefore accumulating) anxiolytics metabolised by oxidation. Alprazolam and clotiazepam also are oxidised compounds but have short to intermediate half-life values and therefore produce considerably less accumulation. Temazepam and lormetazepam are hypnotic agents with intermediate half-lives but metabolised by conjugation. The most unique of the newer benzodiazepines are the ultra-short half-life (oxidised) compounds midazolam, triazolam and brotizolam, which are essentially non-accumulating during multiple dosage. |
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Authors:
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D J Greenblatt; M Divoll; D R Abernethy; H R Ochs; R I Shader |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Clinical pharmacokinetics Volume: 8 ISSN: 0312-5963 ISO Abbreviation: Clin Pharmacokinet Publication Date: 1983 May-Jun |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7606849 Medline TA: Clin Pharmacokinet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 233-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alprazolam Anti-Anxiety Agents / metabolism* Azepines / metabolism Benzodiazepines / metabolism Benzodiazepinones / metabolism Humans Kinetics Lorazepam / analogs & derivatives, metabolism Midazolam Temazepam / metabolism Triazolam / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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MH-34223/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Azepines; 0/Benzodiazepinones; 12794-10-4/Benzodiazepines; 22316-47-8/clobazam; 23092-17-3/halazepam; 28911-01-5/Triazolam; 28981-97-7/Alprazolam; 57801-81-7/brotizolam; 59467-70-8/Midazolam; 846-49-1/Lorazepam; 846-50-4/Temazepam; 848-75-9/lormetazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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